Seminario - Biotecnologie e Bioscienze - Thursday, June 29, 2023, 4:30 pm, BIOS Building, Room U3-07 / Webex
Eduardo Villablanca, Karolinska Institutet, Stockholm, Sweden
Abstract
The complex cellular network that constitutes the intestinal barrier is crucial for maintaining health and preventing diseases. In this talk, I will present the remarkable capabilities of spatial transcriptomics (ST) in unveiling the molecular organization of the entire colonic tissue during mucosal healing and tumorigenesis. By leveraging ST, we revealed a previously undiscovered regionalization of the colon's transcriptomic landscape under steady state conditions, which undergoes dramatic changes during mucosal healing. We identified spatially organized transcriptional programs that define compartmentalized mucosal healing, including regions exhibiting dominant wired pathways. Furthermore, I will discuss the translational potential of our findings by mapping transcriptomic modules associated with human diseases.
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Host: Francesco Strati
LINK to attend the seminar: https://unimib.webex.com/unimib-it/j.php?MTID=mf2febffb717189c1f8a74e90ecbf2d8b
password: day29 (32929 from telephones and video systems)
The seminar is OPEN to all.
tag: #BtBsSeminars . #StratiLab_BtBs