Seminar - Biotechnology and Biosciences - Thursday 29 May 2025, 2:30 pm, BIOS-U3 building, room U3-08
Stefano Mattarocci, Université Paris-Saclay, CEA, Inserm, Institut de biologie François Jacob, France
Abstract
The telomere DNA-protein complex plays a crucial role in maintaining genome stability by protecting chromosome ends from loss and fusion. Specialized telomere-bound DNA factors inhibit the Non-Homologous End Joining (NHEJ) repair pathway, thus preventing terminal chromosomal fusion events. The precise molecular mechanisms by which these telomere proteins regulate the recruitment and activity of the NHEJ machinery remain poorly understood. Here, I will present novel molecular insights into how Rap1, the key protein associated with Saccharomyces cerevisiae telomeres, modulates the activity of two key NHEJ repair factors, the KU and MRX complexes.
Host: Diego Bonetti
The seminar is OPEN to all.
ONLINE REGISTRATION for the seminar is a mandatory requirement for those who wish to request the CERTIFICATE OF ATTENDANCE, which, together with the signature on the ATTENDANCE SHEET, will confirm actual participation.
Registration will open on Monday, May 26.