Gianni Frascotti

• MICROBIAL PHYSIOLOGY, METABOLISM AND PRODUCTIONS

MICROBIAL PHYSIOLOGY, METABOLISM AND PRODUCTIONS

Microbial cells are used to obtain several products and metabolites of wide interest, such as organic acids, enzymes and hormones. The physiology and the metabolic routes of the producing host cells are deeply studied, coupling molecular biology, transcriptomic and metabolomic techniques with chemostat studies and flow cytometric single cells analyses. Productions in flasks are then optimised in fermentators, in order to increase yield and to minimise the duration and costs of the whole processes. The same multidisciplinary approach is used to minimise the stress induced in the host cells by the production process itself and to understand the principle of cellular stress answer in general.

Partecipants: Brambilla Luca Giuseppe , Branduardi Paola , Frascotti Gianni , Porro Danilo