- Role: Ricercatore
- Assignments:Membro della Giunta di Dipartimento
- Office:U4 stanza 5020
- Telephone number:02- 64483526
- Reception Hours:Su appuntamento via e-mail
Recent findings have extended our knowledge about metabolic changes in cancer cells. Metabolic processes are often altered to meet the demands of abnormally proliferating cancer cells. For example, the Warburg effect observes that cancer cells increase glucose uptake and the rate of glycolysis even under normoxic conditions, termed aerobic glycolysis. In addition, several tumors show also an alteration of glutamine metabolism and mitochondria dysfunctions. Importantly this metabolic rewiring is often depending on oncogenes expression and tumor suppressor inactivation. Moreover mitochondrial dysfunctions, involved in the onset of the Warburg effect, are sometimes also associated with the resistance to apoptosis that characterizes cancer cells.
The group is currently pursuing three main lines of research, focusing on:
The characterization in different cancer cell lines, mainly carrying K-ras mutations, of the cell death and survival mechanisms activated by glucose deprivation.
Identification of the role of ER and mitochondria in the (de)regulation of the cell death and survival mechanisms under nutrient stress.
Identification of the role of the Hexosamine pathway in cancer cell death/survival, migration and metastasis.
In vitro and in vivo characterization of a new inhibitor of Hexosamine Pathway able to induce cell proliferation arrest and death both in breast and pancreatic tumors.
Training and Research experience
Ferdinando Chiaradonna is Assistant Professor and principal Investigator at the Biotechnology and Bioscience Dept, University of Milano-Bicocca (Italy). He graduated cum laude (1993) in Biological Sciences at the University of Naples (Italy), and earned a Ph.D. (2005) in Life Science at European Institute of Oncology (Milan, Italy) and at Open University, (London, UK).
He worked on different topics, like the characterization of human urokinase post-traslational modifications and their role in enzyme function; characterization of human urokinase receptor ability to bind vitronectin in mammary carcinoma; the definition of the role of viral protein Nef in myelocytic chemotactic and adhesive properties; the identification of the molecular mechanisms involved in monocytic motility and adhesion; the analysis of the cytoskeletal rearrangement in myelocytic cell lines induced to differentiate by various agents (1993-1997);
the identification of novel genes involved in Acute Promyelocitic Leukemia onset; (1997-2002).
His current projects involved the study of signal transduction and molecular mechanisms of cell cycle control and the relationship between cellular transformation and the metabolic alterations characterizing cancer cells with particular emphasis in the metabolic alterations associated to cell death. Systems dynamics of cell proliferation and death with a focus to cancer cell models. More info http://www.sysbio.it
Roberta Palorini, Ph.D.
Francesca Ricciardiello, Ph.D.
Laura Bergamaschi, Master student
Marco Giampà, Master student
Membro della Giunta di Dipartimento