The research activity, in the field of Biochemistry and Molecular Biology, has been related to:
1. Regulation of growth and cell cycle in eukaryotes
2. Molecular cloning, expression and secretion of heterologous protein in budding yeast
3. Molecular cloning, biochemical and molecular characterization of activator of Ras protein in yeast and in higher eukaryotes.
The present research activities are related to the understanding of mechanism of signal transduction in eukaryotes:
1) Nutrient sensing and growth regulation in budding yeast, with a particular interest for Ras/cAMP pathway and Phospholipase/Calcium pathway
2) Mechanism of signal transduction that activate small G-protein Ras and Ras-like in the central nervous system of mammals and in neuronal cell line (PC-12).
3) Expression of recombinant human-NGF in mammalian cells for therapeutical applications.
SIGNAL TRANSDUCTION IN EUKARYOTIC CELLS
Signal transduction is studied both in yeast and in human cells. In Saccharomyces cerevisiae we study one of the main signalling transduction pathways, the Ras/cAMP/adenylate cyclase pathway, finely tuning pKA activity in the cell and leading to the mobilization of storage carbohydrates, the activation of glycolytic enzymes and the inhibition of gluconeogenesis.
Partecipants: Colombo Sonia , Martegani Enzo , Tisi Renata
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Enzo Martegani – Full Professor
room 5019, V floor , building U3
tel: +39 02 6448 3533
see also: PubMed, BOA, #BtBsPub
last update April 2017