nov 112018
erasmus 72dpi

erasmus 72dpi
Erasmus Seminars 2018 – Gene regulation and human disease

Genetic and cellular mechanisms in brain development and disease
New experimental technologies, new horizons of understanding

directed to Erasmus, Masters and PhD students in Biology/Biotechnology/Medicine, and all interested researchers. Students will receive introductory papers to read before the talks.

download the program

Friday afternoon (15:30; some talks may be earlier, see below + updates), room U3-06

Paola Bovolenta (Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid) POSTPONED TO JANUARY 11 15:30, room U3-06
How genes orchestrate the development of the visual system, in the normal and in genetic vision disease: insights from functional genomics and targeted mutations in zebrafish
Tools: ChIPseq and RNAseq analysis of ex-vivo cells; CRISPR/Cas9 genome editing in vivo (zebrafish)
November 9, 15:30: Alessandro Sessa (San Raffaele Scientific Institute, Milano)
SETD5, a new epigenetic player in neural development
Tools: engineering of disease-relevant mutations in neural cells

November 16, 12:30: Steve Pollard (MRC Centre for Regenerative Medicine, the University of Edinburgh)
Gene regulation in glioblastoma-initiating cancer stem cells: approaches to identify drivers of cancerogenesis
Tools: tumor-initiating cells in vitro culture, genetic manipulation, and functional genomics

November 23: Antonello Mallamaci (International School of Advanced Studies – SISSA, Trieste)
Homeotic transcription factors in cerebral cortex development and tumorigenesis
Tools: human iPS cells neural differentiation and genetic modification

January 18: Benedikt Berninger (Institute of Psychiatry, Psychology & Neuroscience, MRC Centre for Neurodevelopmental Disorders, London; University of Mainz)
Molecular steps in the direct in vivo reprogramming of differentiated pericytes to neurons involve transition through a stem cell gene expression program
Tools: in vivo reprogramming of non-neural cells to active neurons; single cell RNAseq

December 17-21: Alumni Bicocca
December 19, 12:00, room 2025: Sara Bottes (Brain Research Institute, University of Zuerich)
Live imaging of neurogenesis in the adult mouse hippocampus. Implications for brain function
Pilz GA, Bottes S et al, Science 2018, 359:658
Tools: live imaging of neurogenesis in the mouse hippocampus via 2-photon microscopy

December 20, 12:00, room 2025: Jessica Mariani (Yale University, New Haven, USA)
Deciphering the genetics of autism spectrum disorders by human iPS cell in vitro differentiation into brain organoids, functional genomics studies, and genome editing
Mariani J et al, Cell 2015, 162:375; Ardhanareesvan, Mariani et al, Nat Rev Neurol 2017, 13:265
Tools: generation and study of brain organoids from normal and mutant human iPS cells

December 21, 12:00, room 2025: Chiara Alberti (Research Institute of Molecular Pathology (IMP), Wien)
A framework for understanding the roles of miRNAs in animal development.
Alberti C et al, Nat Methods 2018, 15:283; Alberti and Cochella, Development 2017, 144:2548
Tools: cell-type-specific miRNA sequencing from ex-vivo cells

For informations about the seminar course, ask the Erasmus coordinator, Biology: Prof. Silvia Nicolis
office: U3, third floor, room 3046

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