gen 142019
 
erasmus 72dpi

erasmus 72dpi
Erasmus Seminars 2018 – Gene regulation and human disease

Genetic and cellular mechanisms in brain development and disease
New experimental technologies, new horizons of understanding

directed to Erasmus, Masters and PhD students in Biology/Biotechnology/Medicine, and all interested researchers. Students will receive introductory papers to read before the talks.

Friday afternoon (15:30; some talks may be earlier, see below + updates), room U3-06

November 9, 2018, 15:30: Alessandro Sessa (San Raffaele Scientific Institute, Milano)
SETD5, a new epigenetic player in neural development
Tools: engineering of disease-relevant mutations in neural cells

November 16, 2018, 12:30: Steve Pollard (MRC Centre for Regenerative Medicine, the University of Edinburgh)
Gene regulation in glioblastoma-initiating cancer stem cells: approaches to identify drivers of cancerogenesis
Tools: tumor-initiating cells in vitro culture, genetic manipulation, and functional genomics

December 17-21, 2018: Alumni Bicocca
December 19, 12:00, room 2025: Sara Bottes (Brain Research Institute, University of Zurich)
Live imaging of neurogenesis in the adult mouse hippocampus. Implications for brain function
Pilz GA, Bottes S et al, Science 2018, 359:658
Tools: live imaging of neurogenesis in the mouse hippocampus via 2-photon microscopy

December 20, 2018, 12:00, room 2025: Jessica Mariani (Yale University, New Haven, USA)
Modeling idiopathic autism in a dish using stem cell derived brain organoids
Mariani J et al, Cell 2015, 162:375; Ardhanareesvan, Mariani et al, Nat Rev Neurol 2017, 13:265
Tools: generation and study of brain organoids from normal and mutant human iPS cells

December 21, 2018, 12:00, room U3-10: Chiara Alberti (Research Institute of Molecular Pathology (IMP), Wien)
A framework for understanding the roles of miRNAs in animal development.
Alberti C et al, Nat Methods 2018, 15:283; Alberti and Cochella, Development 2017, 144:2548
Tools: cell-type-specific miRNA sequencing from ex-vivo cells

January 11, 2019: Paola Bovolenta (Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid)
How genes orchestrate the development of the visual system, in the normal and in genetic vision disease: insights from functional genomics and targeted mutations in zebrafish
Tools: ChIPseq and RNAseq analysis of ex-vivo cells; CRISPR/Cas9 genome editing in vivo (zebrafish)

January 18, 2019, 12:00, room U1-11, building U1: Benedikt Berninger (Centre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders. Institute of Psychiatry, Psychology & Neuroscience, King’s College London.)
Engineering neurogenesis for the postnatal and adult brain
Tools: in vivo reprogramming of non-neural cells to active neurons; single cell RNAseq

, 2019: Antonello Mallamaci (International School of Advanced Studies – SISSA, Trieste)
Homeotic transcription factors in cerebral cortex development and tumorigenesis
Tools: human iPS cells neural differentiation and genetic modification

For informations about the seminar course, ask the Erasmus coordinator, Biology: Prof. Silvia Nicolis
silvia.nicolis@unimib.it
office: U3, third floor, room 3046

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