Genetic and molecular mechanisms in cellular biology and pathology: implications for human disease


This research area includes 11 research groups having a common interest in the study of molecular and genetic mechanisms of normal and pathological cellular functions. These basic science studies, that are in several cases carried out in collaboration with researchers active in experimental medicine, represent a starting point towards the exploration of mechanisms underlying important human pathologies, such as cancer, hereditary diseases, neurodegeneration and senescence, and bacterial infection. These groups are highly competent in several research areas, and their methods and approaches are widely shared, favoring important cultural and experimental interactions (cellular and animal models, genomics, proteomics, stem cells, genetics of eukaryotic and prokaryotic microorganisms).

Molecular control of erythripoiesis
Antonella Ronchi

Studi su cellule staminali tissutali marcate da un transgene GFP, controllato da sequenze regolative del gene c-Kit
Sergio Ottolenghi

Proteins involved in human pathologies
Paola Fusi

La riparazione delle rotture del DNA
Michela Clerici

Molecular mechanisms involved in aneuploidy formation
Roberta Fraschini

Mechanisms controlling genome integrity
Maria Pia Longhese

Molecular mechanisms of signal transduction in mammalian cells and their role in human disease
Michela Ceriani

Il ruolo del fattore trascrizionale Sox2 nello sviluppo del sistema nervoso, nelle cellule staminali neurali e nei tumori cerebrali
Silvia Nicolis

Post-transcriptional regulation of mammalian gene expression
Silvia Barabino

Aging and cell death
Marina Vai
Ivan Orlandi

Nutrient or stress responsive signal transduction in Saccharomyces cerevisiae
Renata Tisi