Feb 172017

webinar 100x100
Monday, February 20, 2017, time 14:00, room 2025, building U3.

Johnathan R. Whetstine, Ph.D. Massachusetts General Hospital Cancer Center Harvard Medical School Charlestown, MA
Mark J. O’Connor, Ph.D AstraZeneca Cambridge, UK

While it is well established that DNA damage can increase the risk of cancer, changes to the epigenome or the chromatin architecture are equally
important. DNA damage triggers a redistribution of DNA-binding proteins around the site of damage, resulting in localized and temporary alteration of
chromatin structure. However, repeated cycles of DNA damage and repair may lead to permanent changes in the epigenome, thereby promoting the
onset of diseases such as cancer. This webinar will examine how we may be able to develop effective new therapeutic options for cancer treatment by
targeting proteins responsible for chromatin modifications.

During the webinar, the speakers will:
Highlight the mechanisms of tumorigenesis and genomic instability resulting from copy number gains
Explain the different forms of DNA damage that lead to genomic instability and tumorigenesis
Investigate how understanding genomic instability can inform the development of cancer treatments

Webinar Time: 61 min

*Is recommended to bring your own headphones to have a better audio quality.

coordinator: Reinaldo Alvarez, reinaldo.alvarez@unimib.it, tel. 3340

Available on-demand >>> cooming soon

download the flyer

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