Seminar in the frame of Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642157
Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach.
venerdì 17 giugno 2016, ore 11:00, Luisella Sironi U4-08,
Dipartimento di Biotecnologie e Bioscienze, Università degli Studi Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Koichi FukaseProfessor, Department of Chemistry, Graduate School of Science, Osaka University
We have studied the synthesis of immunostimulating and immunomodulating glycoconjugates from microbes and ourselves to elucidate their action mechanism in innate immunity and acquired immunity. We are now focusing the new methods for immunoregulation by using microbial and animal glycans as well as by the modification of glycan structures toward the future therapeutic applications, i.e., development of immune adjuvants and vaccines, anti-cancer therapy, anti-allergy therapy, and so on. Our strategy for immunoregulation is 1) immunostimulation through innate immune receptors such as TLR4, TLR2, Nod1, and Nod2, 2) synergistic immunostimulation by conjugation of innate immune receptor ligands, 3) immunomodulation through CD1d ligands from Entamoeba histolytica , 4) control of cell surface glycan structures of hosts, and 5) the use of glycan antigens. Based on these strategies, we synthesized various natural and designed glycoconjugates. Their immunoregulatory activity will be also described.
Ospite: Prof. Francesco Peri