The Research Group in Experimental Pathology of Professor Costea is currently hosting Gloria Campioni, a student of the PhD course in Converging Technolo-gies for Biomolecular System (TeCSBi), Department of Biotechnology and Bioscience at University of Milano-Bicocca (Italy). She is here for 3 months to learn how to generate in vitro 3D multi-cellular cancer models and to study the effect of fibroblasts on the metabolic rewiring of resistance pathways in cancer.
Gloria’s doctoral project aims to develop complex models of mammary carcino-ma, such as spheroids from breast cancer cell lines and organoids from patient derived xenografts, in order to study cancer metabolic rewiring. Breast cancer is the most frequent and deathly cancer in women, and it is considered a very heterogeneous disease, so more complex models are necessary to better represent this type of tumor and its microenvironment. Her lab group in Italy, lead by Professor Marco Vanoni, is interested in systems biology and in studying in vitro cancer metabolic plasticity, also through the development of three-dimensional tumor models.
source: CCBIO – newslwtter - Capturing cancer complexity and clinical challenges, No.5, Vol.7, 20 oct 2020.