“Cell-autonomous stress responses in innate immunity and inflammation”

seminario ANNULLATO

lunedì 11 febbraio 2019, ore 11:30, aula 2025, edificio U3

Evelina Gatti, PhD, HDR – Research Director at CNRS, Dendritic Cell Biology Laboratory, CIML – Centre d’Immunologie de Marseille-Luminy Marseille – France & Professor of Molecular Immunology – “Ilidio Pinho” Chair IBiMED – Health Sciences and Department of Medical Sciences University of Aveiro – Portugal

keywords: endosomal dynamic, autophagy, protein synthesis, integrated stress response, immunomodulation, dendritic cells, antigen processing and presentation, ubiquitination, innate sensing and signaling.

related publications:

– Perego J, Mendes A, Bourbon C, Camosseto V, Combes A, Liu H, Manh TV, Dalet A, Chasson L, Spinelli L, Bardin N, Chiche L, Santos MAS, Gatti E, Pierre P. 52 (2018). Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2? dephosphorylation by the GADD34/PP1c complex. Sci Signal. 2018 Jan 23;11(514). pii: eaam8104. doi: 10.1126/scisignal.aam8104.

– De Angelis Rigotti, F., de Gassart, A., Pforr, C., Cano, F., N’guessan, P., Combes, A., et al. (2017). MARCH9-mediated ubiquitination regulates MHC I export from the TGN. Immunology and Cell Biology, 95(9), 753-764. http://doi.org/10.1038/icb.2017.44

– Combes, A., Camosseto, V., N’guessan, P., Arg?ello, R. J., Mussard, J., Caux, C., et al. (2017). BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells. Nature Communications, 8(1), 913. http://doi.org/10.1038/s41467-017-00695

– Dalet, A., Arg?ello, R. J., Combes, A., Spinelli, L., Jaeger, S., Fallet, M., et al. (2017). Protein synthesis inhibition and GADD34 control IFN?? heterogeneous expression in response to dsRNA. The EMBO Journal, 36(6), 761-782. http://doi.org/10.15252/embj.201695000

– Terawaki, S., Camosseto, V., Prete, F., Wenger, T., papadopoulos, A., Rondeau, C., et al. (2015). RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4. The Journal of Cell Biology, 210(7), 1133-1152. http://doi.org/10.1083/jcb.201501059

– Wenger, T., Terawaki, S., Camosseto, V., Abdelrassoul, R., Mies, A., Catalan, N., et al. (2012). Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation. Autophagy, 8(3), 350-363. http://doi.org/10.4161/auto.18806

Ospite: Prof.ssa Francesca Granucci

scarica la locandina

+ #inflammation