Reinaldo Alvarez

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giovedì 6 luglio 2017, ore 14:30, aula U3-07, edificio U3

Giuliana Giannuzzi, PhD, Center for Integrative Genomics, University of Lausanne, Switzerland

Segmental and gene duplications in the human genome are important for human genetic variation, disease and evolution. They represent human genome trade-offs between the potential adaptive function of duplicated genes mapping to these segments and their potential priming of pathogenic rearrangements.

One example is the 16p11.2 locus, where recurrent copy number variation (CNV) is mediated by a complex set of segmental duplications. The deletion and duplication are associated with autism, schizophrenia, and reciprocal defects in head size and body weight. We reconstructed the evolutionary history of the locus and discovered that it had been dramatically reorganized during hominid evolution. This series of genomic changes includes the Homo sapiens-specific duplication of a 95 kbp segment containing the BOLA2 (BolA family member 2) gene, a gene involved in iron homeostasis, approximately 282 thousand years ago. This duplication that predisposes our species to the recurrent pathogenic 16p11.2 CNV, is absent from the genomes of our extinct relatives Neanderthal and Denisovan. It is apparently under selection (P<0.0097) and nearly fixed in the human lineage.

This region exemplifies that in the future we should comprehensively study and understand the role of structurally composite and repetitive regions of the human genome in disease, complex traits and human-specific features. To this aim it will be crucial to extend the study to other relevant regions that predispose to pathogenic rearrangements while embedding human-specific genes, such as the 1q21, 2q13 and 10q11 cytobands. These complex loci are usually overlooked in genome-wide studies due to analytical issues, requiring dedicated efforts to their investigation.

Ospite: Prof. Luca De Gioia

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lug 012017
 

seminario-100x100
martedì 4 luglio 2017, ore 11:00, aula 2025, edificio U3

Nicola Segata , Lab. of Computational Metagenomics, Centre for Integrative Biology, University of Trento

info:
SegataLab web page: http://segatalab.cibio.unitn.it/
Nicola Segata Twitter: @nsegata
Segata Lab Twitter: @cibiocm

Se siete interessati ad assistere al seminario, per motivi organizzativi legati all’aula, mandate una mail di conferma a maurizio.casiraghi@unimib.it

Ospite: Scuola di Dottorato BTBS

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giu 212017
 
avatar1

logo_TOLLerant

mercoledì 12 luglio 2017, ore 9:00-13:00, aula U4-8, edificio U4

TOLLerant Workshop

Organizer: Prof. Francesco Peri – Coordinator of the MSCA-ETN project TOLLerant

12th July 2017
Room Sironi (Aula U408), Building U4,
University of Milano-Bicocca

      09.00-09.15 Welcome address: Prof. Francesco Peri
      09:15 – 10:00 “Cell-Surfaced Carbohydrate-Protein Interactions and Origami Art”
      Dr Shang-Cheng Hung, Ph.D. – Genomics Research Center Academia Sinica Taipei, Taiwan
      10:00 – 10:45 “Chemistry on Free Sugars and Stereoselective Glycosylation Reactions”
      Cheng-Chung Wang Ph.D. – Institute of Chemistry, Academia Sinica. Taipei, Taiwan
      10.45-11.15 Coffee break
      11:15 – 12:00 “Synthesis and Function of Bacterial Glycoconjugates for Regulation of Immune System”
      Atsushi Shimoyama, Ph. D., Assistant Professor – Department of Chemistry, Graduate School of Science, Osaka University
      12:00 – 12:45 “Challenges in Cancer Vaccine Development by Regulating Immune Responses”
      Koichi Fukase, Ph. D., Professor – Department of Chemistry, Graduate School of Science, Osaka University
      12.45-13.00 Closing remarks
      13.15 – Lunch (Speakers)

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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 64

giu 192017
 

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seminario-100x100
mercoledì 21 giugno 2017, ore 10:30-13:00 // 14:30-17:00, P.zza della Scienza, edificio U4, aula U4-8

Giornata di studio dedicata alla ricerca scientifica di Milano-Bicocca negli oceani e negli spazi marini.

Interverranno esponenti dei gruppi di ricerca dell’ateneo attivi, in vari ambiti disciplinari, nel campo delle scienze marine.
In questa occasione verranno presentate le linee e le prospettive di lavoro sviluppate in due decenni di impegno scientifico.

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giu 082017
 
LogoAlternanza mini

LogoAlternanza
venerdì 7 luglio 2017, ore 14:00, aula U3-08, edificio U3

nel corso dell’ ultimo anno il nostro Dipartimento ha realizzato diverse iniziative in collaborazione con studenti e insegnanti che hanno coperto vari aspetti, tra cui l’ alternanza scuola lavoro, il Piano Lauree Scientifiche, le attività di orientamento per studenti e insegnanti.

Se siete curiosi e desiderate un aggiornamento, avete proposte e suggerimenti, siete disponibili a contribuire alle attività del prossimo anno, siete cordialmente invitati a partecipare.

BtBs: Scuola-Lavoro-Orientamento

Maurizio Casiraghi, Michela Clerici, Marina Lotti, Isabella Mauri, Paolo Tortora, Ivan Orlandi

altre informazioni: Progetto alternanza Scuola/Lavoro a BtBs

giu 082017
 
applikon

applikon

martedì 20 giugno 2017, ore 11:00 – 16:00, aula U1-05, edificio U1

La S.V. è invitata a partecipare al seminario ad ingresso libero previa registrazione tenuto da :
Alex Boscolo e Michel Kensler di Applikon Biotechnology, Philip Mathuis CEO di Ovizio
PROGRAMMA
11.00 – 11.15 Welcome
11.15 – 12.00 Challenges and opportunities for Down Scale in R & D (Alex Boscolo)
12.00 – 12.45 Lucullus Software: Turning Big Data into information (Michel Kensler)
12.45 – 13.00 Coffee break or Lunch
13.00 – 13.45 SMART cell culture monitoring, application of an inline 3D holographic
microscope in biotech processes (Philip Mathuis )
13.45 – 14.30 micro-Matrix: cultivating in 24 parallel microbioreactors; Applications
(Alex Boscolo)
14.30 – 15.30 Coffee/Tea/Drinks

info:
Gianluca Lotito 349 7483656, gianluca.lotito@steroglass.it
Lisa Falocci 075609091, lisa.falocci@steroglass.it

Come raggiungere il seminario:

Scarica la scheda di adesione seminario APPLIKON 2017

Ospite: Prof. Luca Brambilla

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mag 282017
 
Boncinelli UNIMIB BtBs

Boncinelli UNIMIB BtBs
mercoledì 31 maggio 2017, ore 10:30, aula U4-08, edificio U4

Edoardo Boncinelli

Il sogno di molti studenti, dottorandi e postDoc è di diventare un giorno dei ricercatori, il Prof. Boncinelli presenterà il percorso che lo ha portato a diventare un genetista di fama mondiale.

Con il Patrocinio del Rettorato dell’Università degli Studi di Milano Bicocca, del Dipartimento di Biotecnologie e Bioscienze e del Dipartimento di Scienze dell’Ambiente e del Territorio

Ospite: Paolo Galli, Direttore MaRHE Center

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mag 222017
 

seminario-100x100
lunedì 29 maggio 2017, ore 14:00, aula U4-8, edificio U4

Stefano Bertacchi , Dipartimento di Biotecnologie e Bioscienze – UNIMIB
Biotecnologo industriale presso Galatea Biotech, spin-off Unimib
Caporedattore di Italia Unita per la Scienza
Autore di “Geneticamente modificati” per Hoepli

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Geneticamente modificati-page-001 - Copia

mag 172017
 
seminario-100x100

seminario-100x100
venerdì 19 maggio 2017, ore 13:30, aula U7-06, edificio U7

Luciana Migliore, Dipartimento di Biologia, Università Tor Vergata, Roma

ABSTRACT

scarica l’abstract

The increasing rate of human-induced environmental changes on coastal ecosystems has created the demand for effective monitoring and management strategies. In particular, descriptors stating the conservation status of seagrass meadows are necessary due to their widespread regression. Beyond the standard methods (fenology, density, etc.), to this end in our laboratory several approaches were followed in the last years including proteomics and enzymatic analyses, synthesis of secondary metabolites and photosynthetic activity. Among the more affordable there are plant secondary metabolites. Furthermore, the plant-associated microbial communities can deserve interesting cues, being so tightly linked to the plants to be considered an integrated structure, the ‘holobiont’.
Total phenols and photosynthetic pigments were measured in 4 seagrass species (Posidonia oceanica, Mediterranean Sea; Cymodocea nodosa and Zostera noltii, Atlantic Ocean; Halophila stipulacea, Red Sea). These demonstrated their effectiveness at different time scales (from days to years), and under different growth conditions (in situ and mesocosm) and environmental pressures (eutrophication to acidification/global warming). The variation of total phenols is associated with environmental stress conditions and thus with a decreasing state of conservation of the meadows. The amount of chlorophyll and carotenoids is a quick response to water column conditions (turbidity). Overall, the results indicate the effectiveness and versatility of the two descriptors: they were able to represent the eco-physiological state of different species under different environmental conditions. Both descriptors should be included in seagrass monitoring to deepen this field, quite unexplored.

Microbial communities play an important role in seagrass meadow dynamics participating in nutrient cycling, nitrogen fixation and detoxification of sulfide in sediments. Plant’s epiphytic microbial communities are probably involved in the supply of nutrients to the plants and their alteration could affect plant growth and survival. The study of the microbial metagenome by different molecular techniques allows a good and quick taxonomic identification, improving the knowledge of these communities. Two different molecular techniques were applied to study the plant’s epiphytic microbial community of Cymodocea nodosa (SSCP fingerprinting) and Halophila stipulacea (pyrosequencing). The microbial community analyses (bacterial diversity, taxonomic composition and phylogenetic relationships) revealed significant differences between above- and below-ground plant compartment; as expected, the environmental conditions drive the composition of epiphytic bacterial assemblages. Different microbial community assemblages were found also on the plants exposed to different environmental conditions. The microbial community composition needs further investigation, to deepen our knowledge about their structure, functions and relationship with the plant. However, it represents a promising tool to be associated with the biochemical descriptors and included in seagrass monitoring.

Ospite: Davide Seveso

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mag 162017
 
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seminario-100x100
venerdì 19 maggio 2017, ore 15:30, aula U7-06, edificio U7

Phanor Hernando Montoya Maya, Director Corales de Paz Cali, Colombia & Research Associate, Nature Seychelles Island Conservation Centre, Amitie, Praslin, Seychelles

Coral reefs are complex and productive ecosystems that encompass the highest biodiversity of any marine ecosystem. To date, we have lost most of the global coral-reef system worldwide due to overfishing, coastal development, sedimentation, marine-based pollution and climate change. This has resulted in the loss of valuable ecosystem services to the livelihoods of millions of people. Designation of no-take Marine Protected Areas (MPA) is one tool to bolster coral reef recovery. Although there is evidence of natural recovery, it has taken almost 20 years to see coral cover at pre-1998 levels. Threats continue and MPAs might not be enough to assist in the recovery of coral reefs. Consequently, more actions are need to promote reef recovery or build reef resilience. Here, I show how “coral gardening” can become a complementary tool which can help MPA managers in meeting coral reef conservation needs

Ospite: Simone Montano

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mag 092017
 
ppc1274_ridotta

ppc1274_ridotta
Orientarsi e scegliere in modo consapevole il proprio futuro universitario dopo il persorso triennale.

Dal 15 al 27 maggio 2017, l’Ateneo presenterà i propri corsi di laurea magistrale e i master e i corsi di perfezionamento. Si tratta dell’offerta formativa per chi ha già una laurea triennale e vuole specializzarsi ulteriormente, ma è anche una occasione per acquisire competenze di alto livello ed essere maggiormente competitivi nel mondo del lavoro.

Biotecnologie Industriali: 23 maggio 2017
dalle 14.00 alle 16.00 aula 9 Edificio U3, Piazza della Scienza, 2 – 20126 Milano
Iscrizione on line tramite l’apposito form

Biologia: 26 maggio 2017
dalle 14.00 alle 18.00 Aula 10
Edificio U3, Piazza della Scienza, 2 – 20126 Milano
Iscrizione on line tramite l’apposito form

altre informazioni:

mag 082017
 
laVerdi AIRC UNIMIB

laVerdi AIRC UNIMIB


CREATIVITÀ, RICERCA e SOLIDARIETÀ

18 e 24 maggio 2017

Tre istituzioni insieme per supportare la ricerca scientifica attraverso la cultura


18 maggio 2017, Ore 20.30
Auditorium di Milano, Fondazione Cariplo, Largo Gustav Mahler, Milano

GIANNI SCHICCHI
Giacomo Puccini

Orchestra sinfonica di Milano – Giuseppe Verdi

Direttore John Axelrod

Biglietti in promozione speciale € 37-42


24 maggio 2017, Ore 20.30
M.A.C. Musica Arte Cultura, Piazza Tito Lucrezio Caro 1, Milano

CONCERTO DI MUSICA DA CAMERA
Musiche di Franck, Grieg, Ysaÿe, Paganini, Vieuxtemps

Allievi dei corsi di perfezionamento dei Maestri Fulvio Luciani e Anton Sorokow, Università di Milano-Bicocca

Biglietti in promozione speciale a € 15


Per prenotazioni scrivere a: francesca.cremonini@laverdi.org – specificando nell’oggetto della mail: AIRC

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mag 072017
 
BtBs Orientamento Tesi

tesibtbs-logo

giovedì 25 maggio 2017, ore 9:30, aula U4-8, edificio U4

Programma

9:30 – Saluto di benvenuto

Interventi per ogni Macroarea di ricerca del Dipartimento

9:35 – “Nanobiotecnologie per studi preclinici”
Prof.ssa Rita GrandoriPresentazione in PDF

10:00 – “Biodiversità, scienze marine e ricerca in campo alimentare”
Dr.ssa Patrizia Di Gennaro, Dr.ssa Francesca BenzoniPresentazione in PDF

10:25 – “Biotecnologie Industriali e Sintetiche”
Prof.ssa Paola BranduardiPresentazione in PDF

10:50 – Intervalo

11:00 – “Meccanismi genetico-molecolari della biologia e patologia cellulare. Implicazioni per la diagnostica e la terapia”
Dr. Ivan OrlandiPresentazione in PDF

11:25 – “Identificazione di target terapeutici e della loro evoluzione con l’invecchiamento: sviluppo di farmaci indirizzati al target”
Prof. Francesco PeriPresentazione in PDF

11:50 – “Biologia dei sistemi”
Prof. Marco VanoniPresentazione in PDF

mag 052017
 
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seminario-100x100
giovedì 18 maggio 2017, ore 13:30, aula U7-06, edificio U7

Mario De Stefano, Università degli Studi della Campania “Luigi Vanvitelli” (Seconda Università di Napoli)

ABSTRACT

scarica l’abstract

In polar and tropical regions, the rates of primary production of the microalgal communities associated with macroalgae, seagrasses and marine invertebrates are comparable or sometimes higher to those of the phytoplankton component. These benthic microalgal communities, which are mainly represented by diatoms, appear to be composed by a limited number of genera, belonging to different growth forms that can be considered fully adapted to the epibenthic lifestyle. In spite of the important ecological role played in the food chain, the biodiversity of epibenthic diatom communities worldwide is still poorly studied and highly underestimated. Moreover, ecological studies on epibenthic diatom communities based on a rigorous taxonomic approach are rare due to the small size of such organisms. Indeed, most of the species have average size less than 20 microns with taxonomic characters not resolvable in light microscopy, so the scanning electron microscopy results the only possible approach for a correct quantitative analysis of such floristic communities. International collaborations, that are destined to continue in the coming years, have been institutionalized within of a multi-year project, which has the purpose to describe the biodiversity and the community structure at genus and/or species level of epibenthic diatoms on different host species (macroalgae, seagrasses, invertebrates, vertebrates) from Polar (Antarctica and Arctic) Mediterranean and tropical Regions. Until now, epiphytic diatoms living on different macroalgae were collected and analyzed from coastal areas of the Antarctic Italian Base “Mario Zucchelli” (Terranova Bay, Ross Sea, Austral Summer 2012, 2013) and four Antarctic foreign research stations: the American base “McMurdo” (McMurdo Sound, Ross Sea, AS 2009/10), the Polish base “H. Arctowski”, the Brazilian base “Comandante Ferraz” and the Chilean “Escudero” (King George Island, South Shetlands, AS 2010/11, 2014, 2015). In tropical areas epibenthic diatom assemblages on seagrasses (Posidonia spp.), on hydrozoans, gastropods, crustaceans and recently marine turtles have been collected. In this presentation an overview of the results of a four-year study on the ecological role of epibenthic diatom communities on Antarctic macroalgae and on tropical species of marine turtles will be given.

Ospite: Davide Seveso

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mag 042017
 
seminario-100x100

seminario-100x100
giovedì 18 maggio 2017, ore 15:30, aula U7-06, edificio U7

Giovanni Strona, European Commission, Joint Research Centre, Directorate D – Sustainable Resources, Bio-Economy Unit, Via Enrico Fermi 2749, 21027 Ispra, Italy

There are more than 8M species on earth, most of which are yet to be described. According to a conservative estimate, we are losing 0.22% of this diversity per year, which means more than two species per hour. The problem is that most extinction events happen unnoticed, since we tend to focus on charismatic species, and to underestimate the huge impact that co-extinctions, that is the loss of consumers following the decline of their resources, may have on biodiversity. Since extinction is a fundamental ecological process, complex natural systems should be robust to species loss. Actually, their complexity is a strong evidence of that. Yet, they are likely not prepared to withstand the current extinction rate, which is one thousand times higher than the natural one. For this, it seems obvious to look at the magnitude of Global Change as the main driver of species loss. In this seminar, I will show that the picture is more complicated, and that the identity of species going extinct is as important as their number

Ospite: Simone Montano

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apr 272017
 
fare scienza oggi

fare scienza oggi

giovedì 4 maggio 2017, ore 16:00
AUDITORIUM GUIDO MARTINOTTI , EDIFICIO U12
UNIVERSITÀ DI MILANO-BICOCCA, VIA VIZZOLA, 5 – MILANO

ne discutono
Luca Carra – Direttore di Scienzainrete
Gianfranco Pacchioni – Prorettore alla Ricerca

in occasione della presentazione del volume
Scienza: quo vadis?
il Mulino
fare scienza oggi copertina

Sarà possibile seguire l’evento in diretta streaming
a Villa di Breme Forno a Cinisello Balsamo.

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apr 102017
 

seminario-100x100

Dottorato di Ricerca in Biotecnologie Industriali

mercoledì 26 aprile 2017, ore 14:00, aula U4-08, edificio U4

Dr. Giulia Callegaro (Doctor Europaeus)
“Fostering Cell Transformation Assay in carcinogenicity assessment: toward in vitro-in silico bridging”

Dr. Damiano Pellegrino Coppola (Doctor Europaeus)
“Acetyl-Coa metabolism and aging: risks and resources”

Dr. Cristina Visentin (Doctor Europaeus)
“Use of a technological platform to screening in vitro and in vivo anti-amyloidogenic drugs able to prevent early neurodegenerative process ”

Dr. Marco Viganò
“ Mesenchymal stem cells for the treatment of musculoskeletal pathologies: focus on tendinopathy”

Dr. Daniele Cesena
“The RNA processing proteins Xrn1 and Rrp6 regulate DNA damage checkpoint activation and telomere metabolism”

giovedì 27 aprile 2017, ore 9:00, aula U6-04, edificio U6

Dr. Alessia D’Aloia
“RalGPS2 interacts with LST1 and supports tunneling nanotubes formation in human bladder cancer cells”

Dr. Gaia De Sanctis (Doctor Europaeus)
“An integrated approach to study Ras-dependent cancer metabolic rewiring in mouse fibroblasts”

Dr. Mara Gilardi (Doctor Europaeus)
“Dissecting the critical role of cancer/endothelial interactions in metastatic cascade through engineered 3D vascularized microfluidic and mesoscale models”

Dr. Michela Bellini
“Development of apoferritin nanoparticles for chemotherapeutic delivery and drug resistance overcoming in breast cancer models”

Dr. Francesca Ricciardiello
“FR051, a novel Hexosamine Biosynthetic Pathway inhibitor, induces cell death in breast and pancreatic cancer models”

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