Reinaldo Alvarez

“Erasmus Seminars 2018 – Gene regulation and human disease”

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Jan 102019
 
erasmus 72dpi

erasmus 72dpi
Erasmus Seminars 2018 – Gene regulation and human disease

Genetic and cellular mechanisms in brain development and disease
New experimental technologies, new horizons of understanding

directed to Erasmus, Masters and PhD students in Biology/Biotechnology/Medicine, and all interested researchers. Students will receive introductory papers to read before the talks.

Friday afternoon (15:30; some talks may be earlier, see below + updates), room U3-06

January 11, 2019: Paola Bovolenta (Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid)
How genes orchestrate the development of the visual system, in the normal and in genetic vision disease: insights from functional genomics and targeted mutations in zebrafish
Tools: ChIPseq and RNAseq analysis of ex-vivo cells; CRISPR/Cas9 genome editing in vivo (zebrafish)

November 9, 2018, 15:30: Alessandro Sessa (San Raffaele Scientific Institute, Milano)
SETD5, a new epigenetic player in neural development
Tools: engineering of disease-relevant mutations in neural cells

November 16, 2018, 12:30: Steve Pollard (MRC Centre for Regenerative Medicine, the University of Edinburgh)
Gene regulation in glioblastoma-initiating cancer stem cells: approaches to identify drivers of cancerogenesis
Tools: tumor-initiating cells in vitro culture, genetic manipulation, and functional genomics

February 8, 2019: Antonello Mallamaci (International School of Advanced Studies – SISSA, Trieste)
Homeotic transcription factors in cerebral cortex development and tumorigenesis
Tools: human iPS cells neural differentiation and genetic modification

January 18, 2019, 12:00, room U1-11, building U1: Benedikt Berninger (Institute of Psychiatry, Psychology & Neuroscience, MRC Centre for Neurodevelopmental Disorders, London; University of Mainz)
Molecular steps in the direct in vivo reprogramming of differentiated pericytes to neurons involve transition through a stem cell gene expression program
Tools: in vivo reprogramming of non-neural cells to active neurons; single cell RNAseq

December 17-21, 2018: Alumni Bicocca
December 19, 12:00, room 2025: Sara Bottes (Brain Research Institute, University of Zurich)
Live imaging of neurogenesis in the adult mouse hippocampus. Implications for brain function
Pilz GA, Bottes S et al, Science 2018, 359:658
Tools: live imaging of neurogenesis in the mouse hippocampus via 2-photon microscopy

December 20, 2018, 12:00, room 2025: Jessica Mariani (Yale University, New Haven, USA)
Modeling idiopathic autism in a dish using stem cell derived brain organoids
Mariani J et al, Cell 2015, 162:375; Ardhanareesvan, Mariani et al, Nat Rev Neurol 2017, 13:265
Tools: generation and study of brain organoids from normal and mutant human iPS cells

December 21, 2018, 12:00, room U3-10: Chiara Alberti (Research Institute of Molecular Pathology (IMP), Wien)
A framework for understanding the roles of miRNAs in animal development.
Alberti C et al, Nat Methods 2018, 15:283; Alberti and Cochella, Development 2017, 144:2548
Tools: cell-type-specific miRNA sequencing from ex-vivo cells

For informations about the seminar course, ask the Erasmus coordinator, Biology: Prof. Silvia Nicolis
silvia.nicolis@unimib.it
office: U3, third floor, room 3046

Jan 082019
 
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external seminars

IFOM-IEO Calendar
Dipartimento di Bioscienze – UNIMI
HSR
Nerviano Medical Sciences – Seminari di Oncologia
IRCCS Istituto di Ricerche Farmacologiche Mario Negri
IBF – Istituto di Biofisica – CNR
INGM
Fondazione IRCCS Istituto Nazionale dei Tumori
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
UNIMI – Dipartimento di Biotecnologie mediche e medicina traslazionale
Fondazione Oncologia Niguarda Onlus

“Modeling idiopathic autism in a dish using stem cell derived brain organoids”

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Dec 182018
 
PDdE

progetto dipartimenti di eccellenza
giovedì 20 dicembre 2018, ore 12:00, aula 2025, edificio U3

Jessica Mariani, Associate Research Scientist, Program in Neurodevelopment and Regeneration, Child Study Center and Department of Neurobiology, School of Medicine, Yale University (New Haven, USA).

Ospit: Silvia Nicolis

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“PhD Seminars”

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Dec 172018
 
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top phd seminars

Dott. Matteo Piazza, Cerbios-Pharma SA Svizzera

MARTEDI’ 18 DICEMBRE 2018, Ore 10.30 – aula U1-04
Conjugation techniques in Medicinal Chemistry

VENERDI’ 21 DICEMBRE 2018, Ore 10.30 – aula U1-04
Antibody-Drug Conjugates (ADCS): scientific innovation and industrial development

Ospite: Prof. Francesco Peri

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“Modelli grafici probabilistici per le bioscienze”

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Dec 112018
 
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seminario-100x100
lunedì 17 dicembre 2018, ore 10:00, aula U1-05, edificio U1

Federico M. Stefanini , Scientific Head DiSIA Lab, Dipartimento di Statistica, Informatica, Applicazioni
Università degli Studi di Firenze

L’estrazione dell’informazione contenuta in grandi basi di dati post-genomici e la loro integrazione con i dati ambientali e medici sono esempi della complessità che caratterizza la moderna “Data Science” statistica.

Come analizzare dati di tipologia, di provenienza e di qualità eterogenee rispettando la strutturazione gerarchica? E’ possibile analizzare i dati senza rinunciare alla quantificazione di tutte le componenti dell’incertezza? Come sfruttare i dati “non sperimentali” e i “Big Data” per supportare azioni di intervento ambientale, medico e/o biotecnologico? Quale ruolo giocano le variabili confondenti? Quale importanza riveste il processo che genera i dati mancanti? Le inferenze ottenute sono trasportabili? E’ presente un qualche meccanismo di selezione implicita del dato?

I modelli grafici probabilistici si sono rivelati uno strumento molto efficace nella Data Science non solo perché le assunzioni vengono rese esplicite e perché il “degree ofbelief’ dell’esperto può essere quantificato e sfruttato insieme ai dati, ma anche per la possibilità di stimare gli effetti causali diretti e indiretti dell’intervento dopo avere verificato che essi siano effettivamente stimabili. Alcuni esempi in ambito biomedico e agrotecnologico saranno utilizzati per illustrare le principali idee alla base della metodologia.

Ospite: Paola Fusi

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“Acetyl-CoA: at the crossroad between metabolism, epigenetics and cell plasticity in pancreatic cancer initiation and prevention”

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Dec 102018
 
PDdE

progetto dipartimenti di eccellenza
lunedì 17 dicembre 2018, ore 12:00, aula 2025, edificio U3

Alessandro Carrer, Department of Cancer Biology, University of Pennsylvania – School of Medicine, Philadelphia.

Ospite: Ferdinando Chiaradonna

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“Homo sapiens, istruzioni per il collaudo. La definizione dell’umano nell’opera di Primo Levi”

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Dec 102018
 
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seminario-100x100
mercoledì 19 dicembre 2018, ore 10:30, aula U4-08, edificio U4

Mario Barenghi , Professore ordinario di Letteratura italiana contemporanea – Università di Milano Bicocca

Ospite: Luca De Gioia

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“Vent’anni di Scienza all’Università di Milano-Bicocca – un percorso per immagini”

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Nov 292018
 
4 dicembre low

4 dicembre
martedì 4 dicembre 2018, ore 16:30, aula U4-08, edificio U4.

Incontro organizzato in occasione della presentazione del volume fotografico dei Dipartimenti di Scienze nell’anno del ventennale dell’Ateneo.
Docenti, ex studenti, studenti proveranno a gettare uno sguardo sui nostri prossimi venti anni.

Intervengono:
Cristina Messa
Marcello Fontanesi
Andrea Zanchi
Alessandro Russo
Gianfranco Pacchioni
Maurizio Casiraghi
Michele Fumagalli

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“Inauguration symposium of the Interdipartimental Mass Spectrometry Center”

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Nov 242018
 
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foto mass spect
martedì 11 dicembre 2018, ore 14:30-17:30, aula U4-08, edificio U4.

14:30 – Welcome addresses
  Marina Lotti, Director of the Department of Biotechnology and Biosciences
  Andrea Zanchi, Director of the Department of Earth and Environmental Sciences
  Marco Orlandi, Department of Earth and Environmental Sciences
  Rita Grandori, Department of Biotechnology and Biosciences
14:45 – Serena Santacesaria, Thermo Fisher Scientific, IT
“Thermo Fisher Scientific: An overview of the Chromatography and Mass Spectrometry Division”
15:00 – Pierpaolo Nebuloni, Thermo Fisher Scientific, IT
“FTMS Orbitrap™: The analyzer that has revolutionized the mass spectrometry world”
15:15 – Maria Perla Colombini, Department of Chemistry and Industrial Chemistry, University of Pisa, IT
“LC/MS as a useful tool to understand/investigate colors in cultural heritage”
15:55 – Coffee Break
16:10 – Pierluigi Mauri, Institute of Biomedical Technologies, National Research Council (CNR), Segrate, IT
“Applications of the Orbitrap technology to clinical proteomics”
16:50 – Frank Sobott, The Astbury Centre for Structural Molecular Biology, University of Leeds, UK
“Applications of the Orbitrap technology to structural biology -A perspective from a 4-year COST experience”
17:30 – Aperitif

Please confirm your participation to silvana.biraghi@thermofisher.com

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“From Research to Business: Innovation Management & Know-how Transfer at the European Molecular Biology Laboratory”

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Nov 102018
 

seminario-100x100
Seminari Scientifici del Dottorato
giovedì 22 novembre 2018, ore 14:00, aula U4-01, edificio U4.

Dr. Jürgen Bauer – EMBLEM Technology Transfer GMBH, Heidelberg, Germany

An overview over the following aspects in innovation management and technology transfer will be given:
– Relevance of know-how and technology transfer
– Types of intellectual property; – Criteria for patentability
– Structure of a patent application; – Processes for IP protection
– Fundamentals in business development; – licensing vs. creation of spin-off

Ospite: Paola Branduardi

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“Agriculture and animal-agroecosystem interactions: Foundations, problems, and new conservation approaches”

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Nov 102018
 

seminario-100x100
venerdì 23 novembre 2018, ore 08:45, aula U3-06, edificio U3.

Giacomo Assandri – (MUSE – UNIPV)

A great portion of animal diversity worldwide inhabits those landscapes devoted to food production. The socio-economic drivers which have been interesting European farmland areas in
the last decades are posing great risks to such delicate systems which have been remained in
equilibrium for millennia.
The theoretical aspects related to this issue will be discussed during the seminar by presenting three recent case studies regarding the Italian Alps agroecosystems. These will provide practical examples to better understand the conflicts (and possible solutions to mitigate them) among agroecosystem management, biodiversity and provisioning of ecosystem services.

Ospite: Andrea Galimberti

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BtBs – Department of Excellence project: Kick off meeting

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Nov 062018
 
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The BtBs project of excellence: Kick off meeting

Il progetto di eccellenza del Dipartimento di Biotecnologie e Bioscienze (BtBs) si focalizza sullo studio dei meccanismi alla base di malattie croniche multifattoriali (tumori e malattie neurodegenerative) e del processo di invecchiamento che con queste condivide molti dei fattori intrinseci, legati alla genetica ed alla fisiologia degli individui, ed estrinseci, come la nutrizione, lo stile di vita e l’ambiente. Tali temi vengono affrontati sotto il profilo della ricerca pre-clinica, didattica e di interazione con la società e i rilevanti portatori di interesse.

BtBs intende proporsi come centro di riferimento per lo sviluppo di una nuova visione sistemica dei meccanismi di innesco e cronicizzazione di malattie e di senescenza allo scopo di progettare nuove e più efficaci strategie di prevenzione e diagnosi. Per raggiungere tale finalità, il Dipartimento realizzerà nuovi laboratori multidisciplinari integrati ed acquisirà nuovi ricercatori capaci di fornire competenze innovative per raggiungere i risultati prefissati. Lo scambio ed il confronto con altri centri di ricerca, le relazioni con il territorio e la collaborazione con le istituzioni garantiranno il trasferimento delle conoscenze e la valorizzazione dei risultati con risvolti concreti sulla qualità della vita.

Oggi il Progetto presenta l’inizio delle proprie attività e mette a fuoco – col contributo di qualificati esperti internazionali – alcune delle sue tematiche chiave.

La Commissione scientifica
Prof. Marco Vanoni
Prof. Maria Pia Longhese
Prof. Massimo Labra
Prof. Davide Prosperi

November 21th, 2018, room “Luisella Sironi” (U4-08)
Dipartimento di Biotecnologie e Bioscienze – UNIMIB, Piazza della Scienza, 4 20126 Milano

the flyer

Program (download the program)

9:00 Marina Lotti & Luca De Gioia welcome and opening
9.30 Marco Vanoni, “The BtBs Department of Excellence Project: aims, strategy and opportunities”
10.00 – Hans V. Westerhoff, SysBA (Systems Biology Amsterdam), Molecular Cell Physiology, VU University Amsterdam
“Eppur si muove: molecular biology does throw dice, with multifactorial disease and ageing ensuing’”
10.50 – coffee break
11.20 – Matteo Moretti, Cell and Tissue Engineering Laboratory, IRCCS Istituto Ortopedico Galeazzi, via Galeazzi, 4, 20161 Milan, Italy
“Advancing in vitro culture systems by engineering 3D human vascularized models”
12.10 – My excellent project: presentation of PhD and Post Doc projects funded by the department project.
Erika Casari, “Synthetic cytotoxicity to target DNA repair in cancer
Carlotta Ciaramelli, “NMR-driven dissection of the neuroprotective effects of natural extracts from edible sources and their main constituents: implications for the prevention of neurodegenerative diseases
Gloria Campioni, “Generation of patient-specific laboratory and computational models for breast cancer precision medicine
Miriam Pagin, “Modelling human brain developmental pathology in a dish by differentiation of iPS cells to neural cells and brain organoids
12.30 – Competitions: Find the title and Art and Science
13.00 – Lunch and poster session
15.00 – Education and training commission, Paola Branduardi, Marina Lotti, Maurizio Casiraghi and Laura Cipolla: “The educational activities of the project”
15:30 – Poster session Awards
15.40 – Adriana Albini, Dipartimento di Medicina e Chirurgia, Università degli Studi di Milano-Bicocca
“Pharmacological prevention of complex diseases and the role of food and diet-derived compounds”
16.30 – Bruce Beutler, Nobel prize for Medicine, Director of the Center for the Genetics of Host Defense and holder of the “Raymond and Ellen Willie Distinguished Chair in Cancer Research”, University of Texas Southwestern Medical Center, USA
“Using forward genetics to study immunity in mice”
17.30 – Amazing aperitif…with surprise

“Cancer metabolism: from detection of potential biomarkers to novel therapuetic targets for cancer stem cells”

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Nov 062018
 
PDdE

progetto dipartimenti di eccellenza
lunedì 12 novembre 2018, ore 12:00, aula 2025, edificio U3

Alice Agliano, The Institute of Cancer Research (ICR), London, UK.

Ospite: Ferdinando Chiaradonna

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“Workshop & Presentation – Meet Wes”

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Nov 062018
 
Microsoft PowerPoint - Wes_general_flyer_editable_ Univ.Mi Bicoc

Microsoft PowerPoint - Wes_general_flyer_editable_ Univ.Mi Bicoc
venerdì 16 novembre 2018, ore 12:30, aula U3-09, edificio U3.

Giuseppe Tasso – Bio-Techne Srl, Simple Western Specialists

Meet Wes
Gel-free, blot free, hands free Western Blotting
Simple Western(TM) reinvents the entire Western Blot workflow, giving researchs a completely automated, gel-free, blot free, hands free walk away solution.
Now supported by over 1100 quality certified Simple Western antibodies from R&D Systems(r) and Novus Biologicals (r)
Mett Wes(TM) and see how Bio-Techne(r) provides all you need to streamline your science, so you have time for your research.

For more information, please e-mail: giuseppe.tasso@bio-techne.com

Ospite: Daniela Ferrari

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“Role of metabolomics in «one health» concept: from food and environment to health”

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Oct 112018
 
PDdE

progetto dipartimenti di eccellenza
lunedì 22 ottobre 2018, ore 12:00, aula U3-06, edificio U3.

Marynka Ulaszewska, Fondazione Edmund Mach, Food Quality and Nutrition Department, Metabolomics Unit, San Michele all’Adige, Trento.

Ospite: Massino Labra

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MicrobiotaMi 2018 meeting

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Oct 012018
 
MicrobiotaMi 2018 UNIMIB BtBs

MicrobiotaMi Twitter

5th – 7th November, 2018. Milan, Italy.

online registration is CLOSED
MicrobiotaMi 2018 a Porte Aperte (FREE) – 5 Novembre 2018
iscrizioni gratuite alla prima giornata del 5 Novembre (posti limitati) – REGISTRAZIONE CHIUSA

This international event is organized as the final event within the European MSCA-ETN project TOLLerant (www.tollerant.eu) and it will focus on molecular aspects of microbiota-host interaction in health and disease.
The aim of this International meeting is to focus on the molecular mechanisms and interactions in health and disease conditions beyond infection, including sensitization, gut-brain communication, aging, cancer, chronic inflammation and autoimmunity.
Motivation for the selection of this topic is that despite a huge increase in genomic, proteomic and metabolomics data that allowed to relate microbiota composition to health and disease of different organs, the molecular mechanisms by which bacteria, viruses and fungi communicate with the host organism remain largely unknown.
In this context the key role is played by the Pattern Recognition Receptors (PRRs), including Toll-like Receptors (TLRs) but also intracellular NLRs and other receptors.

YOUNG RESEARCHERS ARE STRONGLY ENCOURAGED TO PRESENT THEIR WORK AS FLASH/ORAL COMMUNICATION OR POSTER PRESENTATION.

Confirmed plenary speakers
Program
Registration ON SITE
info: https://microbiotami.com/
contacts: https://microbiotami.com/meeting-contacts/

“GE Healthcare microscopy solutions from widefield to high content confocal acquisition”

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Sep 202018
 
GE 1

GE
giovedì 27 settembre 2018, ore 10:00, aula U3-10, edificio U3.

Philippe Wurtz, Sales Specialist, GE Healthcare Life Sciences.

Key topics will be:
– The new DV Ultra high resolution microscope
– Integrated deconvolution
– Live Cell imaging
– IN Cell HCS Analyzers, confocal vs. non-confocal
– High Speed, High Sensitivity and Flexibility
– SmartScan for tissue or spheroid detection
Contact: manuela.notti@ge.com

Ospite: Roberta Fraschini

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“Chemical Tools for Mucopolysaccharidosis Therapeutic Development”

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Sep 172018
 
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top Ronzoni
mercoledì 19 settembre 2018, ore 11:00, aula U3-05, edificio U3.

organizzatori: Dipartimento di Biotecnologie e Bioscienze ed Istituto Ronzoni

Prof. Vito Ferro, University of Queensland, Australia

Mucopolysaccharidosis (MPS) disorders are a group of lysosomal storage diseases characterised by a deficiency or lack of the enzymes required to degrade glycosaminoglycans, including heparan sulfate (HS). This results in the accumulation of undegraded HS substrate within the lysosome, which leads to significant cell, tissue and organ damage with associated progressive physical and cognitive decline and a shortened lifespan. The affected organs include the heart, bones, joints, respiratory system and central nervous system. There are no cures for MPS disorders, although some treatments are available for a subset of these disorders, principally bone marrow transplant and enzyme replacement therapies. However, the latter are limited by their extraordinary cost and the fact that they are unable to cross the blood-brain barrier or penetrate into joints. In this presentation, I will describe our efforts to develop small molecule approaches to treatment: pharmacological chaperone therapy and substrate reduction therapy. I will also describe the development of a new LC-MS/MS assay for quantitation of HS in biological samples, which is useful for diagnosis and prognosis of MPS disorders and for monitoring the efficacy of new therapies.

Ospite: Prof. Francesco Peri, Dott. Marco Guerrini

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“Sviluppo di nanosistemi bioispirati come strumento di ‘comunicazione’ con il microambiente infiammatorio”

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Sep 162018
 
PDdE

progetto dipartimenti di eccellenza
giovedì 20 settembre 2018, ore 10:30, aula U3-08, edificio U3.

Roberto Molinaro, Department of Cardiovascular Medicine, Harvard Medical School, Boston, MA

Sviluppo di nanosistemi bioispirati come strumento di ‘comunicazione’ con il microambiente infiammatorio

Ospite: Davide Prosperi

Seminario nell’ambito del Progetto Dipartimenti di Eccellenza (PDdE)

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“Demo dello strumento X-Clarity”

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Sep 132018
 
X-Clarity

X-Clarity
lunedì 17 settembre 2018, ore 12:00, aula 2026, piano 2, edificio U3.

Damiano Mangione, Sales Representative Twin Helix S.r.l.

The X-CLARITY™ is a collection of systems and ready-to-use reagents developed by Logos Biosystems to make electrophoretic tissue clearing simple, rapid, and efficient.

Ospite: Davide Prosperi

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