Reinaldo Alvarez

Oct 192018
 
seminario-100x100

external seminars

IFOM-IEO Calendar
Dipartimento di Bioscienze – UNIMI
HSR
Nerviano Medical Sciences – Seminari di Oncologia
IRCCS Istituto di Ricerche Farmacologiche Mario Negri
IBF – Istituto di Biofisica – CNR
INGM
Fondazione IRCCS Istituto Nazionale dei Tumori
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
UNIMI – Dipartimento di Biotecnologie mediche e medicina traslazionale
Fondazione Oncologia Niguarda Onlus

“Role of metabolomics in «one health» concept: from food and environment to health”

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Oct 112018
 
PDdE

progetto dipartimenti di eccellenza
lunedì 22 ottobre 2018, ore 12:00, aula U3-06, edificio U3.

Marynka Ulaszewska, Fondazione Edmund Mach, Food Quality and Nutrition Department, Metabolomics Unit, San Michele all’Adige, Trento.

Ospite: Massino Labra

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, #BtBsPDdE

MicrobiotaMi 2018 meeting

 Communications  Comments Off on MicrobiotaMi 2018 meeting
Oct 012018
 
MicrobiotaMi 2018 UNIMIB BtBs

MicrobiotaMi Twitter

5th – 7th November, 2018. Milan, Italy.

online registration is CLOSED
MicrobiotaMi 2018 a Porte Aperte (FREE) – 5 Novembre 2018
iscrizioni gratuite alla prima giornata del 5 Novembre (posti limitati) – REGISTRAZIONE CHIUSA

This international event is organized as the final event within the European MSCA-ETN project TOLLerant (www.tollerant.eu) and it will focus on molecular aspects of microbiota-host interaction in health and disease.
The aim of this International meeting is to focus on the molecular mechanisms and interactions in health and disease conditions beyond infection, including sensitization, gut-brain communication, aging, cancer, chronic inflammation and autoimmunity.
Motivation for the selection of this topic is that despite a huge increase in genomic, proteomic and metabolomics data that allowed to relate microbiota composition to health and disease of different organs, the molecular mechanisms by which bacteria, viruses and fungi communicate with the host organism remain largely unknown.
In this context the key role is played by the Pattern Recognition Receptors (PRRs), including Toll-like Receptors (TLRs) but also intracellular NLRs and other receptors.

YOUNG RESEARCHERS ARE STRONGLY ENCOURAGED TO PRESENT THEIR WORK AS FLASH/ORAL COMMUNICATION OR POSTER PRESENTATION.

Confirmed plenary speakers
Preliminary Program
Registration ON SITE
info: https://microbiotami.com/
contacts: https://microbiotami.com/meeting-contacts/

“GE Healthcare microscopy solutions from widefield to high content confocal acquisition”

 Seminars  Comments Off on “GE Healthcare microscopy solutions from widefield to high content confocal acquisition”
Sep 202018
 
GE 1

GE
giovedì 27 settembre 2018, ore 10:00, aula U3-10, edificio U3.

Philippe Wurtz, Sales Specialist, GE Healthcare Life Sciences.

Key topics will be:
– The new DV Ultra high resolution microscope
– Integrated deconvolution
– Live Cell imaging
– IN Cell HCS Analyzers, confocal vs. non-confocal
– High Speed, High Sensitivity and Flexibility
– SmartScan for tissue or spheroid detection
Contact: manuela.notti@ge.com

Ospite: Roberta Fraschini

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“Chemical Tools for Mucopolysaccharidosis Therapeutic Development”

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Sep 172018
 
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top Ronzoni
mercoledì 19 settembre 2018, ore 11:00, aula U3-05, edificio U3.

organizzatori: Dipartimento di Biotecnologie e Bioscienze ed Istituto Ronzoni

Prof. Vito Ferro, University of Queensland, Australia

Mucopolysaccharidosis (MPS) disorders are a group of lysosomal storage diseases characterised by a deficiency or lack of the enzymes required to degrade glycosaminoglycans, including heparan sulfate (HS). This results in the accumulation of undegraded HS substrate within the lysosome, which leads to significant cell, tissue and organ damage with associated progressive physical and cognitive decline and a shortened lifespan. The affected organs include the heart, bones, joints, respiratory system and central nervous system. There are no cures for MPS disorders, although some treatments are available for a subset of these disorders, principally bone marrow transplant and enzyme replacement therapies. However, the latter are limited by their extraordinary cost and the fact that they are unable to cross the blood-brain barrier or penetrate into joints. In this presentation, I will describe our efforts to develop small molecule approaches to treatment: pharmacological chaperone therapy and substrate reduction therapy. I will also describe the development of a new LC-MS/MS assay for quantitation of HS in biological samples, which is useful for diagnosis and prognosis of MPS disorders and for monitoring the efficacy of new therapies.

Ospite: Prof. Francesco Peri, Dott. Marco Guerrini

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“Sviluppo di nanosistemi bioispirati come strumento di ‘comunicazione’ con il microambiente infiammatorio”

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Sep 162018
 
PDdE

progetto dipartimenti di eccellenza
giovedì 20 settembre 2018, ore 10:30, aula U3-08, edificio U3.

Roberto Molinaro, Department of Cardiovascular Medicine, Harvard Medical School, Boston, MA

Sviluppo di nanosistemi bioispirati come strumento di ‘comunicazione’ con il microambiente infiammatorio

Ospite: Davide Prosperi

Seminario nell’ambito del Progetto Dipartimenti di Eccellenza (PDdE)

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“Demo dello strumento X-Clarity”

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Sep 132018
 
X-Clarity

X-Clarity
lunedì 17 settembre 2018, ore 12:00, aula 2026, piano 2, edificio U3.

Damiano Mangione, Sales Representative Twin Helix S.r.l.

The X-CLARITY™ is a collection of systems and ready-to-use reagents developed by Logos Biosystems to make electrophoretic tissue clearing simple, rapid, and efficient.

Ospite: Davide Prosperi

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“Identificazione e caratterizzazione di nuovi biomarcatori e target terapeutici mediante studi di proteomica, genomica e sviluppo di anticorpi”

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Sep 112018
 
logo_Primm

Primm
lunedì 17 settembre 2018, ore 14:30, aula 2025, edificio U3.

Angela Pontillo e Elena Canidio, Primm Srl (http://www.primmbiotech.com/)

Abstract
Primm intende promuovere presso l’Università di Milano-Bicocca la propria progettualità scientifico-tecnologica attraverso un seminario dedicato a profili applicativi dell’innovazione illustrando argomenti affrontati nell’ambito di un Progetto di Ricerca e Sviluppo Europeo, applicato nel 7° Programma Quadro dal titolo “SYBIL: Systems biology for the functional validation of genetic determinants of skeletal diseases”.

Ospite: Paolo Tortora

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L’Estetica della Ricerca e la Ricerca dell’Estetica

 Communications  Comments Off on L’Estetica della Ricerca e la Ricerca dell’Estetica
Sep 092018
 

L’Estetica della Ricerca e la Ricerca dell’Estetica
Concorso di arti visive e grafiche per Studenti

“La scienza è noiosa. L’arte è stupida. Dimostrateci che non è vero!”

Il termine per la presentazione dei lavori è il 15 settembre 2018.

Recita così l’incipit di un concorso che si tiene alla Stanford University.
L’idea ci ha molto divertito e anche noi abbiamo deciso di farci convincere del contrario dai nostri studenti. Stupiteci!

regolamento concorso artistico

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“Separazione Cellulare ad Alta Velocità MoFlo Astrios EQ: Tecnologia e Applicazioni”

 Seminars  Comments Off on “Separazione Cellulare ad Alta Velocità MoFlo Astrios EQ: Tecnologia e Applicazioni”
Sep 052018
 

Moflo Astrios
lunedì 10 settembre 2018, ore 10:30, aula 2025, edificio U3.

Jorge Formaro, Beckman Coulter

Programma
10.30 – 11.30 Separazione cellulare ad alta velocità MoFlo Astrios EQ : Tecnologia e Applicazioni
11.30 – 12.00 Q & A

Informazioni:
Massimo Consorti
Beckman Coulter s.r.l.
Via Roma,108 – Edificio F1 Cassina de’ Pecchi (MI)
Cell. 335 7263840
e-mail: mconsorti@beckman.com

Ospite: Antonella Ronchi

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SUMMER SCHOOL “TOWARDS A BIO-BASED ECONOMY: science, innovation, economics, education”

 Communications  Comments Off on SUMMER SCHOOL “TOWARDS A BIO-BASED ECONOMY: science, innovation, economics, education”
Aug 152018
 

Summer School

DURATION: 5 Days
DATES: September 3rd-8th, 2018
APPLICATION DEADLINE: May 31st, 2018

COURSE DESCRIPTION

Bio-based economy (Bioeconomy) aims to reduce the dependence on fossil fuels and finite materials without overexploiting natural resources. According to the definition of the European Commission “Bioeconomy encompasses those parts of economy that use renewable biological resources from land and sea to produce food, biomaterials, bioenergy and bioproducts”. Behind bioeconomy there is much science related to industrial biotechnology as well as a deep change in economics, politics, and societal issues.

A new cross-sector expertise is therefore required. This summer school aims to provide a broad overview of the above-mentioned issues and will be held by national and international speakers, both from academia and from industry. At least one visit to a company involved in the production of bio-based compounds will be included in the school schedule. Because of its inter-disciplinarity, the program welcomes participants with different backgrounds. Participants should be aware that a basic knowledge of the scientific basis of biotechnology is required. Potential participants can ask organizers for advice.

Networking and discussion among students and lecturers will be encouraged and fostered throughout the duration of the school, with social events and a poster session.

CONTENTS
What’s new: Introduction to the scope, challenges and trends of bioeconomy. Local vs global: Choice and processing of renewable raw materials; environmental sustainability of biomass sourcing and processing. How to do it: Key technologies for the production of bio-based products. Biorefineries: concepts and application.
National and international strategies for bioeconomy: funding, organization, network.
Innovation in place: visit to a company and case studies of success (or failure) stories.

PROGRAM COORDINATOR: Prof.sa MARINA LOTTI
REQUIRED DOCUMENTS TO BE UPLOADED IN THE APPLICATION FORM: CV and Passport/ID card, Motivation Letter.
TARGET AUDIENCE: Priority will be given to participants holding a masters degree, but application by masters students is encouraged and will be evaluated on the basis of the applicant’s motivation and background

INFO: marina.lotti@unimib.it

more information: >>>

APPLY NOW

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“Workshop: BD FACSAria™ Fusion Cell Sorter”

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Aug 012018
 
BD1

BD
4 Settembre 2018, ore 10:30, aula 2025, edificio U3.

Dr. Gianluca Rotta, PhD, Product & Scientific Affairs Manager Research Solutions – BD Biosciences. http://www.bd.com/it/

Agenda:

10.30 – 11.00 – Introduzione e teoria del Cell Sorting
11.00 – 11.30 – Strumentazione BD FACSAria Fusion – Lo stato dell’arte nel cell sorting e della Bio Safety
11.30 – 12.00 – Nuove frontiere del cell sorting: purificare le Extracellular Vesicles

Ospite: Prof.ssa Antonella Ronchi

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“High-Content Analysis (HCS) Operetta”

 Seminars  Comments Off on “High-Content Analysis (HCS) Operetta”
Jul 092018
 
operetta

operetta
seminario tecnico-scientifico

Friday, July 13, 2018 – 10:00-12:00, room U3-08, Building U3

10.00: Intro from Massimo Carucci, Cellular Imaging Sales Specialist South EU PerkinElmer
10.20: Intro to HCS from Veronique BerchetHCS Field Application Specialist
10.50: HCS Applications and Analysis from Veronique BerchetHCS Field Application Specialist
11.30: a scientist’s view from Dott.ssa Marta Giacomello, Dip. Di Biologia Università di Padova
12.00 Chiusura

Host: Dott. Ferdinando Chiaradonna

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“Seahorse XF Presentation: Live Cell Metabolic Analysis”

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Jul 082018
 
Agilent horse

Agilent
seminario tecnico-scientifico

Friday, July 13, 2018 – 13:30-15:30, room U3-08, Building U3

Agilent Seahorse XF Analysis uses label-free technology to detect discrete changes in cell bioenergetics in real-time, providing a window into the critical functions driving cell signaling, proliferation, activation, toxicity and biosynthesis. Seahorse instruments, sensor cartridges, assay kits and software combine seamlessly to provide powerful metabolic data from live cells in real-time for the most comprehensive assessment of cell metabolism.

SPEAKERS INFORMATION

Emma Nora Di Capua, PhD. Seahorse Product Specialist Italy/Spain
Laura Cassina, PhD. “Studying the alterations of mitochondrial structure and function in Polycystic Kidney Disease”. Molecular Basis of Cystic Kidney Disorders Unit Division of Genetics and Cell Biology. San Raffaele Scientific Institute

Host: Dr. Elena Sacco

Features: Seahorse XFe96 Analyzer

FLYERS
5991-8657EN_seahorse_plastics_brochure
Immuno Tech Flyer 100517
ImmunologyBrochure_web
Stem Cell Brochure

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“European Summer School on Industrial Biotechnology (ESSIB2018)”

 Communications  Comments Off on “European Summer School on Industrial Biotechnology (ESSIB2018)”
Jun 062018
 
ESSIB_Logo_14_small

Summer School

European Summer School on Industrial Biotechnology (ESSIB2018)

Marine Biotechnology
Naples, 8-12th October, 2018

The European Summer School on Industrial Biotechnology (ESSIB) is organized by the University of Milano-Bicocca (Department of Biotechnology and Biosciences), the University of Stuttgart (Institute of Biochemistry and Technical Biochemistry), and the Universitat Autònoma de Barcelona (Department of Chemical, Biological and Environmental Engineering). ESSIB addresses PhD students and postdocs, preferentially from European laboratories, and will take place every year in a different country and with a different focus.
ESSIB is a complete educational program based on lectures, practical laboratory experience, and contacts with companies active in the field.
ESSIB is an intensive one-week course from Monday to Friday.
Lectures and laboratory courses will be provided by local and invited speakers.

Course description
The Marine Biotechnology Summer School will address gaps such as: developing innovative uses of underutilised and waste material from fisheries and aquaculture to achieve zero waste; using biotechnology and information technology to develop smart, efficient, traceable food systems and create synergies between aquaculture and fisheries; unlocking the potential of microbiomes in aquaculture, fisheries, food processing and biotechnology; applying the latest developments in data mining (machine learning, big data) to the Blue Bioeconomy; creating predictive tools to improve the identification and targeting of biodiversity “hot-spots” in the oceans (-omics based technologies); exploring synergies with land-based production in areas such as food and feed processing, biomaterials, chemicals and nutrients and including waste streams from aquatic to terrestrial value chains; improving aquaculture and fisheries by using biotechnology to create innovative feeds, new chemical compounds to be implemented in the pharmaceutical industry.

Major topics:
1. Biomolecules and pharmaceuticals
2. Biomaterials
3. Bioremediation
4. Use of fishery discards as raw materials
5. Aquaculture
6. Marine litter
7. Reducing, reuse, and recycling to achieve circular economy

Laboratory courses:
1. From samples to molecules (Institute of Protein Biochemistry)
2. A long experience in marine ecology (Stazione Zoologica Anthon Dorn)

Fees and registration
The policy of this Summer School is to keep fees as low as possible in order to support the participation of young
researchers. Fees for this year are still to be determined, but will not exceed 500 €, including accommodation and lunch. A limited number of fellowships will be available to participants without traveling funds. Please inquire by mail.

To apply, please send by May 31, 2018
– a CV including current research topics
– a motivation letter
– a supporting letter by your supervisor to ESSIB2018@unimib.it

We will ask you to register and pay for the fees after this deadline.

Organisers and location
Donatella de Pascale
Fortunato Palma Esposito

Institute of Protein Biochemistry – IBP-CNR
National Research Council of Italy

Via Pietro Castellino, 111
80131 Naples, ITALY

More details at: http://www.ESSIB.eu

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“Workshop – Interaction between nanomaterials and the immune system: medical exploitations and safety issues”

 Communications  Comments Off on “Workshop – Interaction between nanomaterials and the immune system: medical exploitations and safety issues”
Jun 032018
 
logo frontiers in Immunology workshop BtBs - UNIMIB

frontiers in Immunology workshop BtBs - UNIMIB
9-10 July, 2018, Department of Biotechnology and Biosciences University of Milano-Bicocca.

Organizers
Francesca Granucci, University of Milano-Bicocca
Frontiers in Immunology
SIICA (Italian Society of Immunology, Clinical immunology and Allergology)

Scientific committee
Francesca Granucci (University of Milano-Bicocca, Milan Italy)
Davide Prosperi (University of Milano-Bicocca, Milan Italy)
Miriam Colombo (University of Milano-Bicocca, Milan Italy)
Ivan Zanoni (University of Milano-Bicocca, Milan Italy)
Diana Boraschi (CNR, Naples, Italy)

Speakers
Maria José Alonso, CIMUS Santiago de Compostela, Spain
Martin Bachmann, Oxford University, UK
Diana Boraschi, CNR Naples, Italy
Albert Duschl, Salzburg University, Austria
Bengt Fadeel, Karolinska Institute, Sweden
S. Moein Moghimi, Durham University, UK
Dan Peer, Tel Aviv University, Israel
Victor Puntes, Val d’Hebron Barcelona, Spain

The workshop will be focused on the interaction of nanoparticle with the immune system. Discussions will be on how the physicochemical characteristics of nanoparticles influence the interaction with and the activation of different components of the innate immune system; how nanoparticles can be exploited for the development of vaccines and for the development of immunosuppressive drugs to treat autoimmune diseases. Aspects, such as immunotoxicity, and immune-related side effects of nanoformulations will be also discussed.

Four submitted abstracts will be selected for oral presentation.
Abstract submission deadline: April 15th, 2018
Free registration by May 15th, 2018 by writing an email to siica.amministrazione@siica.it (with subject line: “Registration to the nanoimmunology meeting – [NAME OF THE PARTICIPANT]”)

@SiicaI
@FrontImmunol

Scientific Program

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“The PhD Course in Converging Technologies for Biomolecular Systems (TeCSBi)”

 Communications  Comments Off on “The PhD Course in Converging Technologies for Biomolecular Systems (TeCSBi)”
Jun 012018
 
logo TeCSBi PhD

TeCSBi PhD Course

Application Deadline: June 7, 2018

Research projects focus on three main pillars:
– Systems and molecular biology approaches for the study of complex biological functions
– Synthetic biology, Bio-organic and Green Chemistry
– Bioprospecting, Management and Valorization of Natural Resources

A maximum of 10 (ten) PhD positions are available:
University scholarships (n°5)
Scholarships funded by the Department (n°3)
Positions of Industrial/Executive PhD (n°1)
Places without scholarships (n°1)

The ‘AIR’ features of TeCSBi:
– Advanced training and collaboration with Industries
– Internationalization
– RRI (Responsible Research and Innovation)

How to apply?
https://www.unimib.it/didattica/dottorato-ricerca/accedere-al-dottorato
English version https://www.unimib.it/unimib-international/phd/how-apply

Coordinator: Prof. ssa Paola Branduardi paola.branduardi@unimib.it
Office manager: Dr. Isabella Mauri isabella.mauri@unimib.it

More information can be found on https://www.unimib.it/didattica/dottorato-ricerca/corsi-dottorato/tecnologie-convergenti-sistemi-biomolecolari-tecsbi

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“Functional characterization of gene regulatory elements of epilepsy-associated genes”

 Seminars  Comments Off on “Functional characterization of gene regulatory elements of epilepsy-associated genes”
May 282018
 
seminario 36x36

seminar 100x100
Tuesday, June 19, 2018 – 14:00, room 2025, Building U3

Ramon Y Birnbaum, Department of Life Sciences, the Ben-Gurion University at the Negev, Israel

Epilepsy is one of the most common neurological disorders. It is a complex and heterogeneous disorder which makes it difficult to precisely diagnose and provide effective treatment. A major and underexplored cause of epilepsy could be mutations in gene regulatory elements, such as enhancers. Disruption of these elements, and subsequently of the gene regulatory networks that are involved in brain development, can lead to early onset of epilepsy, such as infantile spasms (IS). This type of epilepsy is linked to an imbalance between glutamatergic projection neurons (excitatory) and GABAergic interneurons (inhibitory). With many IS-associated genes being important for forebrain inhibitory GABAergic interneuron development and function, disruption of the gene regulatory networks in these inhibitory interneurons could lead to IS. Using chromatin immuneprecipitation followed by deep sequencing (ChIP-Seq) with enhancer marks (H3K27ac, RNAPoll2), we identified transcriptional enhancer candidates during differentiation of human embryonic stem cells into inhibitory interneurons. Using RNA-seq, we determined the expression of IS-associated genes and their potential regulated enhancers. In addition, several candidate sequences showed spatiotemporal neuronal activity with high similarity to their potential regulated genes using zebrafish transgenic enhancer assays. Combined, this study provides a novel dataset of the regulatory landscape that controls the spatiotemporal gene expression during inhibitory interneurons and highlights genomic regions in the human genome where mutations could lead to IS and other epilepsies.

about Dr. Ramon Birnbaum

Host: Antonella Ronchi

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“Development of novel therapeutics based on antibody mimetics”

 Seminars  Comments Off on “Development of novel therapeutics based on antibody mimetics”
May 252018
 
logo TeCSBi PhD

up di TeCSBi PhD
Seminari Scientifici del Dottorato
Tuesday, June 5, 2018 – 11:00, room U3-09, Building U3

Dott. Brian Rudkin, Stem Cell & Brain Research Institute, Inserm, University of Lyon

Abstract
While systems biology approaches analyzing the genome, proteome, interactome, metabolome, etc. are increasing our understanding of complex regulatory and metabolic networks, identification of key proteins that regulate cellular responses and underlying metabolism, remains crucial for furthering our understanding of normal cellular processes and pathological perturbations thereof. Antibody mimetics, called “Peptide aptamers”, conceived to conceptually resemble antibodies, are small combinatorial proteins with a constant scaffold presenting a variable region. Their use for the identification and validation of novel targets and discovery of novel therapeutics in vitro, in cellular models, and in vivo in animal models for human disease, will be discussed, underlining the challenge afforded by their packaging and delivery.

Host: Prof. Francesco Peri

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“THE PhDJOURNAL CLUB” 4 giugno

 Seminars  Comments Off on “THE PhDJOURNAL CLUB” 4 giugno
May 252018
 
logo TeCSBi PhD

PhD Journal Club

LUNEDI’ 4 GIUGNO 2018
Ore 9.30 – aula 2025
THE PhDJOURNAL CLUB

Pooja Jayaprakash
A new laboratory evolution approach to select for constitutive acetic acid tolerance in Saccharomyces cerevisiae and identification of causal mutations
Daniel González‐Ramos et al. Biotechnol Biofuels (2016) 9:173

Luis Ferraz
Improvement of yeast tolerance to acetic acid through Haa1 transcription factor engineering: towards the underlying mechanisms
Swinnen et al. Microb Cell Fact (2017) 16:7

A CLOSER LOOK INTO PhD PROJECTS: METHODOLOGIES AND TECHNOLOGIES
Luca Saponari
Non-destructive methods for ecological study on reef-associated macroinvertebrate communities: a short review

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