lunedì 29 ottobre 2018, ore 12:00, aula 2025, edificio U3.
Alberto Magi, Dep. Experimental and Clinical Medicine, University of Florence.
Ospite: Silvia Barabino
– IFOM-IEO Calendar
– Dipartimento di Bioscienze – UNIMI
– Nerviano Medical Sciences – Seminari di Oncologia
– IRCCS Istituto di Ricerche Farmacologiche Mario Negri
– IBF – Istituto di Biofisica – CNR
– Fondazione IRCCS Istituto Nazionale dei Tumori
– Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
– UNIMI – Dipartimento di Biotecnologie mediche e medicina traslazionale
– Fondazione Oncologia Niguarda Onlus
5th – 7th November, 2018. Milan, Italy.
online registration is CLOSED
MicrobiotaMi 2018 a Porte Aperte (FREE) – 5 Novembre 2018
iscrizioni gratuite alla prima giornata del 5 Novembre (posti limitati) – REGISTRAZIONE CHIUSA
This international event is organized as the final event within the European MSCA-ETN project TOLLerant (www.tollerant.eu) and it will focus on molecular aspects of microbiota-host interaction in health and disease.
The aim of this International meeting is to focus on the molecular mechanisms and interactions in health and disease conditions beyond infection, including sensitization, gut-brain communication, aging, cancer, chronic inflammation and autoimmunity.
Motivation for the selection of this topic is that despite a huge increase in genomic, proteomic and metabolomics data that allowed to relate microbiota composition to health and disease of different organs, the molecular mechanisms by which bacteria, viruses and fungi communicate with the host organism remain largely unknown.
In this context the key role is played by the Pattern Recognition Receptors (PRRs), including Toll-like Receptors (TLRs) but also intracellular NLRs and other receptors.
YOUNG RESEARCHERS ARE STRONGLY ENCOURAGED TO PRESENT THEIR WORK AS FLASH/ORAL COMMUNICATION OR POSTER PRESENTATION.
giovedì 27 settembre 2018, ore 10:00, aula U3-10, edificio U3.
Philippe Wurtz, Sales Specialist, GE Healthcare Life Sciences.
Key topics will be:
– The new DV Ultra high resolution microscope
– Integrated deconvolution
– Live Cell imaging
– IN Cell HCS Analyzers, confocal vs. non-confocal
– High Speed, High Sensitivity and Flexibility
– SmartScan for tissue or spheroid detection
Ospite: Roberta Fraschini
mercoledì 19 settembre 2018, ore 11:00, aula U3-05, edificio U3.
organizzatori: Dipartimento di Biotecnologie e Bioscienze ed Istituto Ronzoni
Mucopolysaccharidosis (MPS) disorders are a group of lysosomal storage diseases characterised by a deficiency or lack of the enzymes required to degrade glycosaminoglycans, including heparan sulfate (HS). This results in the accumulation of undegraded HS substrate within the lysosome, which leads to significant cell, tissue and organ damage with associated progressive physical and cognitive decline and a shortened lifespan. The affected organs include the heart, bones, joints, respiratory system and central nervous system. There are no cures for MPS disorders, although some treatments are available for a subset of these disorders, principally bone marrow transplant and enzyme replacement therapies. However, the latter are limited by their extraordinary cost and the fact that they are unable to cross the blood-brain barrier or penetrate into joints. In this presentation, I will describe our efforts to develop small molecule approaches to treatment: pharmacological chaperone therapy and substrate reduction therapy. I will also describe the development of a new LC-MS/MS assay for quantitation of HS in biological samples, which is useful for diagnosis and prognosis of MPS disorders and for monitoring the efficacy of new therapies.
Ospite: Prof. Francesco Peri, Dott. Marco Guerrini
giovedì 20 settembre 2018, ore 10:30, aula U3-08, edificio U3.
Roberto Molinaro, Department of Cardiovascular Medicine, Harvard Medical School, Boston, MA
Sviluppo di nanosistemi bioispirati come strumento di ‘comunicazione’ con il microambiente infiammatorio
Ospite: Davide Prosperi
Seminario nell’ambito del Progetto Dipartimenti di Eccellenza (PDdE)
lunedì 17 settembre 2018, ore 12:00, aula 2026, piano 2, edificio U3.
Damiano Mangione, Sales Representative Twin Helix S.r.l.
The X-CLARITY™ is a collection of systems and ready-to-use reagents developed by Logos Biosystems to make electrophoretic tissue clearing simple, rapid, and efficient.
Ospite: Davide Prosperi
lunedì 17 settembre 2018, ore 14:30, aula 2025, edificio U3.
Angela Pontillo e Elena Canidio, Primm Srl (http://www.primmbiotech.com/)
Primm intende promuovere presso l’Università di Milano-Bicocca la propria progettualità scientifico-tecnologica attraverso un seminario dedicato a profili applicativi dell’innovazione illustrando argomenti affrontati nell’ambito di un Progetto di Ricerca e Sviluppo Europeo, applicato nel 7° Programma Quadro dal titolo “SYBIL: Systems biology for the functional validation of genetic determinants of skeletal diseases”.
Ospite: Paolo Tortora
L’Estetica della Ricerca e la Ricerca dell’Estetica
Concorso di arti visive e grafiche per Studenti
“La scienza è noiosa. L’arte è stupida. Dimostrateci che non è vero!”
Il termine per la presentazione dei lavori è il 15 settembre 2018.
Recita così l’incipit di un concorso che si tiene alla Stanford University.
L’idea ci ha molto divertito e anche noi abbiamo deciso di farci convincere del contrario dai nostri studenti. Stupiteci!
lunedì 10 settembre 2018, ore 10:30, aula 2025, edificio U3.
Jorge Formaro, Beckman Coulter
10.30 – 11.30 Separazione cellulare ad alta velocità MoFlo Astrios EQ : Tecnologia e Applicazioni
11.30 – 12.00 Q & A
Beckman Coulter s.r.l.
Via Roma,108 – Edificio F1 Cassina de’ Pecchi (MI)
Cell. 335 7263840
Ospite: Antonella Ronchi
DURATION: 5 Days
DATES: September 3rd-8th, 2018
APPLICATION DEADLINE: May 31st, 2018
Bio-based economy (Bioeconomy) aims to reduce the dependence on fossil fuels and finite materials without overexploiting natural resources. According to the definition of the European Commission “Bioeconomy encompasses those parts of economy that use renewable biological resources from land and sea to produce food, biomaterials, bioenergy and bioproducts”. Behind bioeconomy there is much science related to industrial biotechnology as well as a deep change in economics, politics, and societal issues.
A new cross-sector expertise is therefore required. This summer school aims to provide a broad overview of the above-mentioned issues and will be held by national and international speakers, both from academia and from industry. At least one visit to a company involved in the production of bio-based compounds will be included in the school schedule. Because of its inter-disciplinarity, the program welcomes participants with different backgrounds. Participants should be aware that a basic knowledge of the scientific basis of biotechnology is required. Potential participants can ask organizers for advice.
Networking and discussion among students and lecturers will be encouraged and fostered throughout the duration of the school, with social events and a poster session.
What’s new: Introduction to the scope, challenges and trends of bioeconomy. Local vs global: Choice and processing of renewable raw materials; environmental sustainability of biomass sourcing and processing. How to do it: Key technologies for the production of bio-based products. Biorefineries: concepts and application.
National and international strategies for bioeconomy: funding, organization, network.
Innovation in place: visit to a company and case studies of success (or failure) stories.
PROGRAM COORDINATOR: Prof.sa MARINA LOTTI
REQUIRED DOCUMENTS TO BE UPLOADED IN THE APPLICATION FORM: CV and Passport/ID card, Motivation Letter.
TARGET AUDIENCE: Priority will be given to participants holding a masters degree, but application by masters students is encouraged and will be evaluated on the basis of the applicant’s motivation and background
more information: >>>
4 Settembre 2018, ore 10:30, aula 2025, edificio U3.
Dr. Gianluca Rotta, PhD, Product & Scientific Affairs Manager Research Solutions – BD Biosciences. http://www.bd.com/it/
10.30 – 11.00 – Introduzione e teoria del Cell Sorting
11.00 – 11.30 – Strumentazione BD FACSAria Fusion – Lo stato dell’arte nel cell sorting e della Bio Safety
11.30 – 12.00 – Nuove frontiere del cell sorting: purificare le Extracellular Vesicles
Ospite: Prof.ssa Antonella Ronchi
Friday, July 13, 2018 – 10:00-12:00, room U3-08, Building U3
10.00: Intro from Massimo Carucci, Cellular Imaging Sales Specialist South EU PerkinElmer
10.20: Intro to HCS from Veronique Berchet – HCS Field Application Specialist
10.50: HCS Applications and Analysis from Veronique Berchet – HCS Field Application Specialist
11.30: a scientist’s view from Dott.ssa Marta Giacomello, Dip. Di Biologia Università di Padova
Host: Dott. Ferdinando Chiaradonna
Friday, July 13, 2018 – 13:30-15:30, room U3-08, Building U3
Agilent Seahorse XF Analysis uses label-free technology to detect discrete changes in cell bioenergetics in real-time, providing a window into the critical functions driving cell signaling, proliferation, activation, toxicity and biosynthesis. Seahorse instruments, sensor cartridges, assay kits and software combine seamlessly to provide powerful metabolic data from live cells in real-time for the most comprehensive assessment of cell metabolism.
Emma Nora Di Capua, PhD. Seahorse Product Specialist Italy/Spain
Laura Cassina, PhD. “Studying the alterations of mitochondrial structure and function in Polycystic Kidney Disease”. Molecular Basis of Cystic Kidney Disorders Unit Division of Genetics and Cell Biology. San Raffaele Scientific Institute
Host: Dr. Elena Sacco
Features: Seahorse XFe96 Analyzer
venerdì 29 giugno 2018, ore 11:00, aula 2025, edificio U3
Damiano Coppola Pellegrino, BtBs, UNIMIB
European Summer School on Industrial Biotechnology (ESSIB2018)
Naples, 8-12th October, 2018
The European Summer School on Industrial Biotechnology (ESSIB) is organized by the University of Milano-Bicocca (Department of Biotechnology and Biosciences), the University of Stuttgart (Institute of Biochemistry and Technical Biochemistry), and the Universitat Autònoma de Barcelona (Department of Chemical, Biological and Environmental Engineering). ESSIB addresses PhD students and postdocs, preferentially from European laboratories, and will take place every year in a different country and with a different focus.
ESSIB is a complete educational program based on lectures, practical laboratory experience, and contacts with companies active in the field.
ESSIB is an intensive one-week course from Monday to Friday.
Lectures and laboratory courses will be provided by local and invited speakers.
The Marine Biotechnology Summer School will address gaps such as: developing innovative uses of underutilised and waste material from fisheries and aquaculture to achieve zero waste; using biotechnology and information technology to develop smart, efficient, traceable food systems and create synergies between aquaculture and fisheries; unlocking the potential of microbiomes in aquaculture, fisheries, food processing and biotechnology; applying the latest developments in data mining (machine learning, big data) to the Blue Bioeconomy; creating predictive tools to improve the identification and targeting of biodiversity “hot-spots” in the oceans (-omics based technologies); exploring synergies with land-based production in areas such as food and feed processing, biomaterials, chemicals and nutrients and including waste streams from aquatic to terrestrial value chains; improving aquaculture and fisheries by using biotechnology to create innovative feeds, new chemical compounds to be implemented in the pharmaceutical industry.
1. Biomolecules and pharmaceuticals
4. Use of fishery discards as raw materials
6. Marine litter
7. Reducing, reuse, and recycling to achieve circular economy
1. From samples to molecules (Institute of Protein Biochemistry)
2. A long experience in marine ecology (Stazione Zoologica Anthon Dorn)
Fees and registration
The policy of this Summer School is to keep fees as low as possible in order to support the participation of young
researchers. Fees for this year are still to be determined, but will not exceed 500 €, including accommodation and lunch. A limited number of fellowships will be available to participants without traveling funds. Please inquire by mail.
To apply, please send by May 31, 2018
– a CV including current research topics
– a motivation letter
– a supporting letter by your supervisor to ESSIB2018@unimib.it
We will ask you to register and pay for the fees after this deadline.
Organisers and location
Donatella de Pascale
Fortunato Palma Esposito
Institute of Protein Biochemistry – IBP-CNR
National Research Council of Italy
Via Pietro Castellino, 111
80131 Naples, ITALY
More details at: http://www.ESSIB.eu
9-10 July, 2018, Department of Biotechnology and Biosciences University of Milano-Bicocca.
Francesca Granucci (University of Milano-Bicocca, Milan Italy)
Davide Prosperi (University of Milano-Bicocca, Milan Italy)
Miriam Colombo (University of Milano-Bicocca, Milan Italy)
Ivan Zanoni (University of Milano-Bicocca, Milan Italy)
Diana Boraschi (CNR, Naples, Italy)
Maria José Alonso, CIMUS Santiago de Compostela, Spain
Martin Bachmann, Oxford University, UK
Diana Boraschi, CNR Naples, Italy
Albert Duschl, Salzburg University, Austria
Bengt Fadeel, Karolinska Institute, Sweden
S. Moein Moghimi, Durham University, UK
Dan Peer, Tel Aviv University, Israel
Victor Puntes, Val d’Hebron Barcelona, Spain
The workshop will be focused on the interaction of nanoparticle with the immune system. Discussions will be on how the physicochemical characteristics of nanoparticles influence the interaction with and the activation of different components of the innate immune system; how nanoparticles can be exploited for the development of vaccines and for the development of immunosuppressive drugs to treat autoimmune diseases. Aspects, such as immunotoxicity, and immune-related side effects of nanoformulations will be also discussed.
Four submitted abstracts will be selected for oral presentation.
Abstract submission deadline: April 15th, 2018
Free registration by May 15th, 2018 by writing an email to email@example.com (with subject line: “Registration to the nanoimmunology meeting – [NAME OF THE PARTICIPANT]”)
Application Deadline: June 7, 2018
Research projects focus on three main pillars:
– Systems and molecular biology approaches for the study of complex biological functions
– Synthetic biology, Bio-organic and Green Chemistry
– Bioprospecting, Management and Valorization of Natural Resources
A maximum of 10 (ten) PhD positions are available:
University scholarships (n°5)
Scholarships funded by the Department (n°3)
Positions of Industrial/Executive PhD (n°1)
Places without scholarships (n°1)
The ‘AIR’ features of TeCSBi:
– Advanced training and collaboration with Industries
– RRI (Responsible Research and Innovation)
Coordinator: Prof. ssa Paola Branduardi firstname.lastname@example.org
Office manager: Dr. Isabella Mauri email@example.com
More information can be found on https://www.unimib.it/didattica/dottorato-ricerca/corsi-dottorato/tecnologie-convergenti-sistemi-biomolecolari-tecsbi
Tuesday, June 19, 2018 – 14:00, room 2025, Building U3
Ramon Y Birnbaum, Department of Life Sciences, the Ben-Gurion University at the Negev, Israel
Epilepsy is one of the most common neurological disorders. It is a complex and heterogeneous disorder which makes it difficult to precisely diagnose and provide effective treatment. A major and underexplored cause of epilepsy could be mutations in gene regulatory elements, such as enhancers. Disruption of these elements, and subsequently of the gene regulatory networks that are involved in brain development, can lead to early onset of epilepsy, such as infantile spasms (IS). This type of epilepsy is linked to an imbalance between glutamatergic projection neurons (excitatory) and GABAergic interneurons (inhibitory). With many IS-associated genes being important for forebrain inhibitory GABAergic interneuron development and function, disruption of the gene regulatory networks in these inhibitory interneurons could lead to IS. Using chromatin immuneprecipitation followed by deep sequencing (ChIP-Seq) with enhancer marks (H3K27ac, RNAPoll2), we identified transcriptional enhancer candidates during differentiation of human embryonic stem cells into inhibitory interneurons. Using RNA-seq, we determined the expression of IS-associated genes and their potential regulated enhancers. In addition, several candidate sequences showed spatiotemporal neuronal activity with high similarity to their potential regulated genes using zebrafish transgenic enhancer assays. Combined, this study provides a novel dataset of the regulatory landscape that controls the spatiotemporal gene expression during inhibitory interneurons and highlights genomic regions in the human genome where mutations could lead to IS and other epilepsies.
about Dr. Ramon Birnbaum
Host: Antonella Ronchi
Seminari Scientifici del Dottorato
Tuesday, June 5, 2018 – 11:00, room U3-09, Building U3
Dott. Brian Rudkin, Stem Cell & Brain Research Institute, Inserm, University of Lyon
While systems biology approaches analyzing the genome, proteome, interactome, metabolome, etc. are increasing our understanding of complex regulatory and metabolic networks, identification of key proteins that regulate cellular responses and underlying metabolism, remains crucial for furthering our understanding of normal cellular processes and pathological perturbations thereof. Antibody mimetics, called “Peptide aptamers”, conceived to conceptually resemble antibodies, are small combinatorial proteins with a constant scaffold presenting a variable region. Their use for the identification and validation of novel targets and discovery of novel therapeutics in vitro, in cellular models, and in vivo in animal models for human disease, will be discussed, underlining the challenge afforded by their packaging and delivery.
Host: Prof. Francesco Peri
LUNEDI’ 4 GIUGNO 2018
Ore 9.30 – aula 2025
THE PhDJOURNAL CLUB
A new laboratory evolution approach to select for constitutive acetic acid tolerance in Saccharomyces cerevisiae and identification of causal mutations
Daniel González‐Ramos et al. Biotechnol Biofuels (2016) 9:173
Improvement of yeast tolerance to acetic acid through Haa1 transcription factor engineering: towards the underlying mechanisms
Swinnen et al. Microb Cell Fact (2017) 16:7
A CLOSER LOOK INTO PhD PROJECTS: METHODOLOGIES AND TECHNOLOGIES
Non-destructive methods for ecological study on reef-associated macroinvertebrate communities: a short review